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人参果皂苷对急性心肌梗塞犬血流动力学的影响
引用本文:何小溪,曲绍春,于晓风,徐华丽,王绚卉,睢大员. 人参果皂苷对急性心肌梗塞犬血流动力学的影响[J]. 吉林大学学报(医学版), 2008, 34(2): 204-208. DOI: 国家九五科技攻关项目资助课题(96-901-05-
作者姓名:何小溪  曲绍春  于晓风  徐华丽  王绚卉  睢大员
作者单位:吉林大学药学院药理学教研室,吉林,长春,130021;吉林大学药学院药理学教研室,吉林,长春,130021;吉林大学药学院药理学教研室,吉林,长春,130021;吉林大学药学院药理学教研室,吉林,长春,130021;吉林大学药学院药理学教研室,吉林,长春,130021;吉林大学药学院药理学教研室,吉林,长春,130021
摘    要:目的:研究人参果皂苷(GFS)对急性心肌梗塞犬血流动力学的影响。方法:30只犬结扎左冠状动脉前降支6 h制备急性心肌梗塞模型,GFS按2.5、5.0和10.0 mg•kg-1分为3个剂量组,静脉滴注给药;阳性对照药生脉注射液(PAI)组静脉滴注PAI 4.0 mL•kg-1;梗塞模型组静脉滴注生理盐水,记录给GFS后犬心功能及血流动力学各参数变化。结果:与模型组比较,GFS 5.0和10.0 mg•kg-1组犬的心率(HR)减慢(P<0.05或P<0.01),收缩压(SBP)、舒张压(DBP)、左心室收缩压(LVSP)、左室压上升最大速率(+dp/dtmax)、左室压下降最大速率(-dp/dtmax)及心输出量(CO)增加(P<0.05或P<0.01),左室舒张期末压(LVEDP)降低(P<0.05或P<0.01),与PAI组比较差异无显著性(P>0.05)。结论:GFS能改善心肌的收缩和舒张功能,缓解心肌梗塞后的泵衰竭,同时能降低心肌耗氧量,有利于增加心肌供血。

关 键 词:人参果皂苷  心肌梗塞  血流动力学  疾病模型  动物
文章编号:1671-587X(2008)02-0204-05
收稿时间:2007-05-20
修稿时间:2007-05-20

Effects of ginseng fruit saponins on hemodynamics in acute myocardial infarction dogs
HE Xiao-xi,QU Shao-chun,YU Xiao-feng,XU Hua-li,WANG Xuan-Hui,SUI Da-yuan. Effects of ginseng fruit saponins on hemodynamics in acute myocardial infarction dogs[J]. Journal of Jilin University: Med Ed, 2008, 34(2): 204-208. DOI: 国家九五科技攻关项目资助课题(96-901-05-
Authors:HE Xiao-xi  QU Shao-chun  YU Xiao-feng  XU Hua-li  WANG Xuan-Hui  SUI Da-yuan
Affiliation:Department of Pharmacology,School of Pharmacy,Jilin University,Changchun 130021,China
Abstract:Objective To study the effects of ginseng fruit saponins(GFS) on hemodynamics in acute myocardial infarction dogs.Methods The acute myocardial infarction models were induced by ligation left anterior descending coronary for 6 h in 30 dogs.GFS was divided into three doses groups(2.5,5.0 and 10.0 mg·kg-1) and administered with intravenous drip.Pulse-activating injection was taken as positive control medicine and administered with intravenous drip.Infarction model group,normal saline was administered with intravenous drip.After treated with GFS(in dosages of 2.5-10 mg·kg-1 iv drip)for 90 min,the changes of parameters of heart function and hemodynamics were recorded.Results Compared with model control group,the heart rate(HR) was slowed(P<0.05 or P<0.01);systolic blood pressure(SBP),diastolic blood pressure(DBP),left ventricular systolic pressure(LVSP),maximum left ventricular rise rate(+dp/dtmax) and maximum left ventricular fall rate(-dp/dtmax) and cardiac output(CO) were increased(P<0.05 or P<0.01) ;and left ventricular end-diastolic pressure(LVEDP) was decreased after treated with GFS(in dosages of 5.0 and 10.0 mg·kg-1 iv drip) for 90 min.Its effect was the same with pulse-activating injection.Conclusion GFS can improve myocardial systolic and diastolic function,and relieve pump failure after myocardial infarction.GFS can also decrease the myocardial volume of oxygen consumption to profit increasing myocardial blood-supply.
Keywords:ginseng fruit saponins  myocardial infarction  hemodynamics  disease model,animal
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