CT 灌注成像参数评估孤立性肺结节的诊断价值--Meta 分析

目的：用 Meta 分析方法评价 CT 灌注成像(CTP)参数对孤立性肺结节(SPN)的诊断价值。方法检索关于 CTP 方法评估 SPN 的文章,查询 PubMed,EMBASE,中国期刊全文数据库(CNKI)、维普(VIP)和万方等数据库,根据 Cochrane 协作网的内容制定文献的纳入与排除标准,对文献进行筛选,评价入选文献的质量并提取特征信息。应用 Review Manager 5.3软件进行数据分析,检验异质性及偏倚情况。结果共纳入17篇文献,包含了877个病灶,由于存在异质性,故采用随机效应模型。软件分析后提示恶性 SPNs 的血容量(BV)值明显高于良性(P <0.00001)。结论在 CTP 中,恶性 SPN 的 BV 值与良性 SPN 的 BV 值存在显著差异,作为 CTP 的血流动力学参数之一,BV 值可以为 SPN 提供鉴别诊断依据。

Value of CT perfusion imaging parameters for assessing the solitary pulmonary nodule-a Meta-analysis

Objective To evaluate the value of CT perfusion imaging (CTP)for solitary pulmonary nodule (SPN)by Meta-analysis.Methods Literatures about SPN diagnosed by CTP were filtered.PubMed,EMBASE,CNKI,VIP and WANFANG databases were searched for the relevant articles.The retrieved studies were screened according to the criteria for diagnostic research published by the cochrane methods group on screening and diagnosis.The quality of the articles was accessed and the basic data in the articles was extracted.Review Manager 5.3 software was used to compare the blood volume (BV)among different nodules,to perform heterogeneity test and analyze publication bias.Results A total of 1 7 studies with 877 lesions were included in the study.The random effect model was used for the existence of heterogeneity.The result showed the BV value of malignant SPN was higher than that of benign ones.Conclusion The result indicates that there exists significant difference in BV between malignant and benign SPN.The BV value,as one of the hemodynamic parameters of CTP,can be used as the diagnostic basis of SPN.