Effect of Amorolfine (Ro 14–4767/002) on in vitro Phagocytosis and Intracellular Killing of Cartdida albicans by Human Neutrophils: Die Wirkung von Amorolfin Po 14–4767/002) in vitro auf Phagozytose und intrazellulare Abtotung von Candida albicans durch menschlische Neutrophile

The effect of amorolfine (Ro 14-4767/002) on phagocytosis and intracellular killing of Candida albicans blastospores was determined in human neutrophil monolayer assays. At 0.2, 2 and 5 micrograms/ml amorolfine did not have any significant inhibitory or enhancing effect on phagocytosis whether following simultaneous addition of blastospores and drug to the neutrophils, prior treatment of neutrophils for 2 h before addition of blastospores or prior treatment of blastospores for 2 h. Simultaneous addition of amorolfine resulted in a significant increase in killing at all concentrations. This increase was not significantly enhanced by either preincubation of neutrophils or blastospores for 2 h with the drug.