慢性乙型肝炎病人结肠粘膜淋巴细胞亚群分析

本文用组织学和免疫组织化学方法对１５例经肝穿刺证实的中、重度慢性乙型病毒性肝炎病人的结肠粘膜进行了免疫病理学研究。发现该组病人结肠粘膜固有层淋巴细胞增多，上皮间淋巴细胞减少；ＣＤ３＋、ＣＤ８＋细胞增多，ＣＤ４＋细胞变化不大；少量上皮细胞有ＨＬＡ－ＤＲ的表达。提示有轻度炎症反应，但炎症程度远不如非特异性结肠炎，且有质的不同。这种轻度炎症反应与中、重度慢性肝炎病人结肠粘膜机械屏障受损、抗原刺激粘膜免疫系统导致局部免疫状态发生改变有关。

Analysis of Lymphocyte Subtypes in Colon Mucosa of Chronic Hepatitis Patients with HBV Infection

In this paper,the immunopatology of colon mucosa of chronic hepatitis patientswith HBV infection was investigated with histological and immunohistochemistrymethods. Fifteen chronic hepatitis patients were included and the diagnosis in allpatients was proved by liver biopsy.The results showed that lumina propria lymphocytes (LPL), CD3+ and CD8+ cell were increased,whereas interepithelial lymphoctes(IEL)were decreased. CD4+ cells had no significant change. HLA-DR antigen waslightly expressed in epithelial cells. These results indicated that inflammation existed in the colon mucosa of the chronic hepatitis group. But it is much less activethan the idiopathic colonitis and the infiltrated lymphocytes was different from thelatter.This light inflammation of colon mucosa might be related to the damage ofmechanical barria in colon mucosa, permitting entry of lumen antigen to stimulatethe lymphocyte proliferation.