The analysis of diagnosis and treatment for pancreatic fistula after pancreaticoduodenectomy for 105 periampullary carcinoma cases

Aim: To investigate the ways in which to decrease the morbidity of pancreatic fistula after pancreaticoduodenectomy and corresponding therapy. Methods: Double-layered end-to-side duct-to-mucosa anastomosis was applied in 105 cases of pancreaticoduodenectomy and pancreaticoenteric reconstruction, postoperative pancreatic fistula cases were treated aggressively by early surgery, effective drainage and enteral nutrition. Results: Ten cases of pancreatic fistula occurred among 105 operative cases and required reoperation. The rest of the cases recovered uneventfully, except for five cases of in-hospital death. Conclusion: Aggressively early surgery, effective drainage, comprehensive treatment and continual improvement of operative technique are the key to dealing with postoperative pancreatic fistula.