颅内转移瘤患者不同个体化治疗方案疗效比较

目的:探讨颅内转移瘤患者最适合的治疗方案,为改善颅内转移瘤患者生存质量及延长生存时间提供依据。方法：本组颅内转移瘤患者186例，根据患者病情及影像学资料分为Ⅰ组（手术+放疗+化疗组）81例、Ⅱ组（放疗+化疗组）66例、Ⅲ组（化疗组）14例、Ⅳ组（放疗组）14例及Ⅴ组（支持治疗组）11例。比较各组患者颅内高压、神经压迫症状治疗的有效率及平均生存期，对可随访到患者的近期和远期疗效进行统计学分析。结果：Ⅰ组患者颅内高压、神经压迫症状治疗的有效率及平均生存期分别较Ⅱ、Ⅲ及Ⅴ组明显提高，差异均有统计学意义(P<0.05)，而Ⅰ组与Ⅳ组组间比较差异无统计学意义(P>0.05)。结论：颅内转移瘤患者要采用个体化治疗方案，对一般状况较好的患者，首选为手术联合放疗和化疗，其次为放疗。

Comparison of clinical efficacy of individualized treatment plan for intracranial metastatic tumor

Abstract:Objective To explore the most appropriate treatment method for the patients with intracranial metastatic tumor，and to provide basis for improving the life quality of the patients and prolonging the living time．Methods 186 cases of intraeranial metastatic tumor in our department form 2000 to 2010 were selected and divided into five groups according to the condition and image data: group Ⅰ (operation + radiotherapy + chemotherapy group) with 81 cases, group Ⅱ (radiotherapy + chemotherapy group) with 66 cases,group Ⅲ (chemotherapy group) with 14 cases, group Ⅳ(radiotherapy group) with 14 cases, Ⅴ group (supportive therapy group) with 11 cases.The nerve compression symptoms and treatment effectiveness of intracranial hypertension and the average survival period of the patients were compared between various groups. The statistics analysis was carried for the patients who were followed up.Results There were significantly differences of nerve compression symptoms and treatment effectiveness of intracranial hypertension and the average survival period between group Ⅰ and group Ⅱ,group Ⅲ,group Ⅴ P<0.05);but there were no significantly differences between group Ⅰ and group Ⅳ(P>0.05).Conclusion Individualized treatment should be used in the patients with intracranial metastatic tumor；operation combined with adiotherapy and chemotherapy is the first choice in the patients with good neurological condition, ollowed by radiotherapy.