胎儿宫内发育迟缓时胎盘病理改变与孕妇血及脐血中一氧化氮 …

目的 了解胎儿宫内发育迟缓（ＩＵＧＲ）时胎病理改变与母血及脐血中一氧化氮（ＮＯ）水平的关系。方法 对１９９７年１１月￣１９９８年１０月３８例妊娠合并胎儿宫内发育迟缓（ＩＵＧＲ组）及３０例正常３０例正常孕妇（对照组）分娩后的胎盘及胎儿附属物进行分析。

The relation between placental pathologic changes and serum nitric oxide levels of maternal and umbilical blood in intrauterine growth retardation

OBJECTIVE: To study the relation between placental pathologic changes and levels of maternal and umbilical serum nitric oxide (NO) in intrauterine growth retardation (IUGR). METHODS: 38 patients with IUGR (IUGR group) and 30 healthy pregnant women in their late trimester (control group) were studied from Nov. 1997 to Oct. 1998. The placenta and the appendages of fetus were studied after delivery. The concentration of serum NO were determined with cortas' method. RESULTS: Placental pathological changes were found in 26 cases of IUGR group (68.42%), and the main pathological changes were growth retardation of villi and villositis. In the control group, 5 out of 30 cases had placental pathological findings (16.67%). There was statistically significant difference between the 2 groups (P < 0.01). In IUGR group, the maternal and umbilical NO concentration in the 26 cases with placental pathological changes decreased significantly when compared with that in 12 cases without obvious pathological findings of placenta (P < 0.05, P < 0.05); NO levels of umbilical cord were higher than that of maternal serum in both groups(P < 0.01, P < 0.05); There was correlation about serum NO concentration between mother and her fetus in both groups (r = 0.5475, r = 0.8506); but umbilical serum NO level was not related to the weight of the newborn (r = 0.2838). CONCLUSION: The obvious placental pathologic changes occurred in patient with IUGR caused noticeably lower NO levels in maternal and umbilical serum.