脑梗死患者血清超敏C-反应蛋白与同型半胱氨酸水平的相关性分析

目的研究脑梗死患者血清超敏C-反应蛋白(hs-CRP)与同型半胱氨酸(Hcy)之间的相关性,探讨其与脑梗死发生的关系和意义。方法以彩色多普勒显像仪检查102例脑梗死患者双侧颈总动脉及颈内动脉颅外段血管,根据粥样硬化斑块的回声强度把患者分为软斑组、硬斑组和无斑块组。患者均取空腹静脉血测定血清hs-CRP、Hcy、叶酸、维生素(Vit)B12、纤维蛋白原(Fib)、白细胞(WBC)及血脂水平。分析脑梗死患者血清hs-CRP与Hcy水平的相关性,比较各组间各检测指标的差异。结果脑梗死患者hs-CRP水平与Hcy水平呈正相关(r=0.465,P<0.01),3组患者各生化指标水平间差别均无统计学意义(P>0.05)。结论在脑梗死患者中,高Hcy血症导致的动脉粥样硬化可能参与了炎性反应过程。

Correlation Analysis between Serum Supersensitive CRP and Homocysteic Acid in Patients with Cerebral Infarction

Objective To approach the correlation between serum supersensitive C-reactive protein(hs-CRP)and homocysteic acid(Hcy)and its relation to occurrence of cerebral infarction(CI)and its significance.Methods The bilateral common carotid arteries and extracranial segments of internal carotid arteries in 102 patients with CI were examined with color Doppler flow imaging.Basing on the echo intensity of atherosclerotic plaques,the patients were divided as soft plaque group,hard plaque group and non-plaque group.The levels of serum hs-CRP,Hcy,folic acid,vitamin B12,fibrinogen,blood fat and WBC of fasting vein blood in all patients were measured.Then the correlation between hs-CRP and Hcy was analyzed,and the differences of every index among groups were compared.Results There was a positive correlation between hs-CRP and Hcy(r=0.465,P <0.01)in patients with CI.There were no statistics difference of indices among groups.Conclusion Homocysteic acid maybe participate the inflammatory reaction process of atherosclerosis in patients with CI.