口服碘油丸对甲状腺自身抗体的影响

观察了山东省重度缺碘病区人群服用４００ｍｇ碘油前后的甲状腺自身抗体水平。服药前甲状腺自身抗体ＴｍＡｂ和ＴｇＡｂ均阴性，而服药一年、一年半和二年后分别出现５、６、１０例抗体阳性患者；服药后的ＴｍＡｂ、ＴｇＡｂ水平均明显高于服药前。提示服用碘油丸很可能会影响甲状腺自身抗体而诱发甲状腺自身免疫性疾病，应引起重视。

Effects of oral iodized oil capsule on thyroid autoantibodies

Iodized oil capsule (400mg) was given to the subjects from a severely iodine-deficient area of Rizhiao in Shandong province. Thyroid autoantibodies, both against the microsomal antigen and thyroglobulin, were negative before treatment, but became positive in five, six and ten subjects one, one and a half, and two years after, respectively. Levels of TmAb and TgAb were higher than that before treatment. These results indicate that: 1) AITO may occur after the administration of iodized oil capsule,possibly because of thyroid autoantibodies existed, and 2) AITD, especially AIT, should be paid attention to in the iodized oil prophylaxis in iodine-deficient area.