Characteristics of Breast Carcinoma Cases With False-Negative Sentinel Lymph Nodes |
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| Affiliation: | 1. Department of Pathology, University of Alabama at Birmingham (UAB), Birmingham, AL;2. Department of Pathology, Mount Sinai Medical Center, New York, NY;1. Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore;2. Life Science Institute, National University of Singapore, Singapore;1. Unité de Catalyse et de Chimie du Solide, UMR CNRS 8181, 59655 Villeneuve d’Ascq cedex, France;2. Université Lille-1–Sciences et Technologies, 59650 Villeneuve d’Ascq cedex, France;3. École Nationale Supérieure de Chimie de Lille, 59655 Villeneuve d’Ascq cedex, France;1. Centre d’écologie fonctionnelle et évolutive, UMR CNRS-UM2 5175, 1919, route de Mende, 34293 Montpellier cedex 5, France;2. Agence de l’environnement et de la maîtrise de l’énergie (ADEME), 20, avenue du Grésillé, BP 90406, 49004 Angers cedex 01, France;3. Faculty of Chemistry, Department of Organic Chemistry, Wrocław University of Technology, Wybrzeże Wyspiańskiego 27, 50-370, Wroclaw, Poland;1. URCMEP (UR11ES85), Faculty of Sciences, University of Gabès, 6029 Gabès, Tunisia;2. National School of Engineers (ENIG), University of Gabès, 6029 Gabès, Tunisia;3. Al Imam Mohammad Ibn Saud Islamic University (IMSIU), College of Sciences, Department of Chemistry, Riyadh 11623, Saudi Arabia |
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| Abstract: | ![]()
BackgroundIn the past decade, sentinel lymph node biopsy (SLNB) has become standard for patients with early-stage clinically node-negative breast carcinoma (BC). Despite high overall surgical identification success rates with introduction of the dual-tracer techniques (dye and radiolabeled probe), false-negative rates remained unchanged in most recent meta-analyses.Patients and MethodsWe analyzed cases with false-negative SLN biopsy results over a 12-year period in a single institution to evaluate their clinicopathologic characteristics. Sixty-three false-negative cases (3.1%) were found in 2043 successful SLN mapping procedures, all of which were followed by varying amounts of additional axillary sampling.ResultsThere was a higher proportion of invasive lobular carcinomas (ILCs; 23 cases [37%]) when compared with this lesion's overall reported frequency (5%-15%). The majority of invasive ductal carcinoma (IDC) cases (31 of 40) were poorly differentiated. In 80% of the ductal-type cases, 1 or more nonsentinel nodes (NSLNs) were completely or partially replaced by tumor, as opposed to less than half of such cases of the lobular type. Twenty-two cases had multiple positive NSLN metastases, which were significantly associated with larger tumor size (≥ 1.0 cm) and tumor replacement of NSLNs. Eighty-two percent of the cases with known hormone receptor status were positive for estrogen or progesterone receptors, or both.ConclusionFalse-negative SLN biopsy results were more often associated with a primary BC characterized by a lobular or poorly differentiated ductal histologic type or partial to complete replacement of NSLNs with tumor, or both. |
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| Keywords: | Axillary lymph node dissection Immunohistochemical analysis Node-negative breast cancer Sentinel lymph node biopsy |
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