| Susceptibility to Vaginal Candidiasis under Different Conditions in Mice |
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| 作者姓名： | 谭娟 李家文 陈善娟 吴艳 覃芳 丁娟 曹菲 张少如 |
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| 作者单位： | Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wahan 430022, China |
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| 基金项目： | This project was supported by grants from the Science Research Foundation of Health Department of Hubei Province （No. JXIB048） and the Janssen Research Foundation. |
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| 摘 要： | In order to study the susceptibility of murine vaginal mucosa to Candida albicans under different conditions, vaginal lavage fluid and vaginal tissue of mice were observed and compared between murine models with normal immune system （estrogen-treated mice） and immunosuppressed murine model, and between primary infection model of vaginal candidiasis and secondary infection one. The average level of colony forming unit （CFU） from the immuosuppressed group was higher than that from estrogen-treated group at each time point and the peak time was delayed. The differences between the two groups were statistically significant （P〈0.05） from the fourth day after inoculation. A significant difference existed in the average level of CFU between the control group and the estrogen-treated group （P〈0.05）, and between the control group and the immuosuppressed group （P〈0.01）. It was concluded that the vaginal mucosa from the immunosuppressed mice is more susceptible to Candida albicans and no difference is found in susceptibility between mice with primary infection and secondary infection.
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| 关 键 词： | 磁化率 阴道感染 念珠菌病 细菌感染 |
| 收稿时间： | 2005-09-27 |
Susceptibility to vaginal candidiasis under different conditions in mice |
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| Tan Juan,Li Jiawen,Chen Shanjuan,Wu Yan,Qin Fang,Ding Juan,Cao Fei,Zhang Shaoru.Susceptibility to Vaginal Candidiasis under Different Conditions in Mice[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2005,25(6):744-746. |
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| Authors: | Tan Juan Li Jiawen Chen Shanjuan Wu Yan Qin Fang Ding Juan Cao Fei Zhang Shaoru |
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| Institution: | Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China |
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| Abstract: | In order to study the susceptibility of murine vaginal mucosa to Candida albicans under different conditions, vaginal lavage fluid and vaginal tissue of mice were observed and compared between murine models with normal immune system (estrogen-treated mice) and immunosuppressed murine model, and between primary infection model of vaginal candidiasis and secondary infection one. The average level of colony forming unit (CFU) from the immuosuppressed group was higher than that from estrogen-treated group at each time point and the peak time was delayed. The differences between the two groups were statistically significant (P<0.05) from the fourth day after inoculation. A significant difference existed in the average level of CFU between the control group and the estrogen-treated group (P<0.05), and between the control group and the immuosuppressed group (P<0.01). It was concluded that the vaginal mucosa from the immunosuppressed mice is more susceptible to Candida albicans and no difference is found in susceptibility between mice with primary infection and secondary infection. |
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| Keywords: | Candida albicans vaginal candidiasis susceptibility mice |
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