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| 体外诱导激活的杀伤细胞对癌细胞的作用 | |
| 引用本文： | 张菊,梁国栋,邓贤碧,张盈华. 体外诱导激活的杀伤细胞对癌细胞的作用[J]. 医学争鸣, 1993, 0(6) |
| 作者姓名： | 张菊 梁国栋 邓贤碧 张盈华 |
| 作者单位： | 唐都医院中心实验室(张菊，梁国栋，邓贤碧)，唐都医院中心实验室(张盈华) |
| 摘 要： | 作者用低浓度(200 U/ml)重组人白细胞介素2(γIL-2)体外诱导人外周血淋巴细胞,研究了体外淋巴因子激活的杀伤细胞(LAK)对传代瘤细胞株的杀伤作用机理。倒置显微镜卜观察。LAK细胞可在体外增殖,较一般淋巴细胞体积增大3～7倍,且在培养96 h后,可见分裂象。在LAK细胞与瘤细胞共育时,LAK细胞对瘤细胞有显著的趋向性,首先接近包围瘤细胞,然后裂解为小效应细胞,攻击进入瘤细胞浆内,致其崩溃死亡。 |
| 关 键 词： | 白细胞介素2 淋巴因子激活的杀伤细胞 瘤细胞 |
Killing effect of LAK cells induced in vitro on cancer cells |
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| ZHANG Ju,LIANG Guo-Dong,DENG Xian-Bi and ZHANG Ying-Hua Clinical Medical Research Centre,Tangdu Hospital. Killing effect of LAK cells induced in vitro on cancer cells[J]. Negative, 1993, 0(6) | |
| Authors: | ZHANG Ju LIANG Guo-Dong DENG Xian-Bi ZHANG Ying-Hua Clinical Medical Research Centre Tangdu Hospital |
| Abstract: | Human PBMC were cultured in low concentration of 7IL-2, then we learned that the mechanism of LAK cells was different from normal lymphocytes. They could propogate in vitro, approach and kill cancer cells. The propogated lymphocyte's volume was 3 to 7 times larger than the normal's. On the other hand, the attacked cancer cells in turn affect LAK cells, they can stimulate LAK cells to propogate. |
| Keywords: | interleukin 2 lymphokine-activated killer cells cancer cells |
| 本文献已被 CNKI 等数据库收录！ | |