| 支扩宁合剂质量标准研究 |
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| 引用本文： | 达庆国,;吴其标,;曹世宏.支扩宁合剂质量标准研究[J].中国药房,2009(15):1160-1162. |
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| 作者姓名： | 达庆国 ;吴其标 ;曹世宏 |
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| 作者单位： | [1]南京中医药大学附属医院,南京市210029; [2]南京中医药大学,南京市210029 |
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| 基金项目： | 江苏省科学技术厅社会发展项目（BS2002062） |
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| 摘 要： | 目的:建立支扩宁合剂的质量标准。方法:采用薄层色谱(TLC)法对制剂中黄芩、桑白皮、枳壳、丹参进行定性鉴别;用高效液相色谱法对制剂中黄芩苷进行含量测定。结果:TLC斑点清晰、分离度好,阴性对照无干扰。黄芩苷的检测浓度在15.81～252.96μg.mL-1范围内与峰面积积分值呈良好的线性关系(r=0.9999);平均回收率为101.8%,RSD=1.80%(n=9)。结论:所建标准可用于支扩宁合剂的质量控制。
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| 关 键 词： | 支扩宁合剂 质量标准 高效液相色谱法 薄层色谱法 |
Quality Standard of Zhikuoning Mixture |
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| Institution: | DA Qing-guo, CAO Shi-hong,WU Qi-biao(The Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029,China;Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China) |
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| Abstract: | OBJECTIVE： To establish the quality standard of Zhikuoning mixture. METHODS： Scutellaria baicalensis, Morus alba, Citrus aurantinm, Salvia rniltiorrhiza in the preparation were identified by TLC, and the content of baicalin in Zhikuoning mixture was determined by HPLC. RESULTS： The TLC spots were clear and well - isolated yet without inter- ference from negative control. The linear range of Baicalin was 15.81～252.96μg·mL^-1（r = 0.999 9） and its average recovery was 101.8% （RSD = 1.80%, n = 9）. CONCLUSION： The established quality standard can be used for the quality control of Zhikuoning mixture. |
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| Keywords: | Zhikuoning mixture Quality standard HPLC TLC |
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