莫沙必利联合氟哌噻吨美利曲辛治疗海员功能性消化不良的临床观察

目的:观察氟哌噻吨美利曲辛治疗海员功能性消化不良(FD)的临床疗效。方法:139例海员FD患者中,心理测评无异常59例为C组,心理测评异常80例随机平均分成A组和B组,3组均给予莫沙必利治疗,A组加用氟哌噻吨美利曲辛,疗程8周。治疗前、后采用消化不良症状评分量表(GSRS)、焦虑自评量表(SAS)、抑郁自评量表(SDS)进行评分。结果:海员FD患者SAS、SDS标准分高于国内常模(P<0.05);治疗后A组及C组GSRS评分显著低于B组(P<0.05),A组SAS和SDS评分也显著低于B组(P<0.05)。结论:海员FD与精神心理因素关系密切,氟哌噻吨美利曲辛既能显著改善消化道症状,又能有效控制抑郁焦虑障碍。

Therapeutic Efficacy of Mosapride plus Flupentixol Melitracen for Functional Dyspepsia of Seamen

OBJECTIVE： To evaluate the efficacy of Flupentixol Melitracen for functional dyspepsia （FD） of seamen. METHODS： A total of 139 seamen with FD were enrolled, of whom, 59 who had no abnormality in abnormal psychologic test were assigned to Group C, another 80 with abnormality in abnormal psychologic test were randomized to Group A or Group C. All the 3 groups received Mosapride, but Group A received additional Flupentixol Melitracen for 8 weeks. Before and after treatment, scores of gastrointestinal symptom rating scale （GSRS）, self-rating anxiety scale （SAS） and self rating depres- sive scale（SDS） were compared. RESULTS： The standard scores of SAS and SDS in FD seamen were higher than the domestic norms（P〈 0.05）; after treatment, the GSRS scores in Group A and Group C were significantly lower than in Group B（P 〈 0.05）, and the scores of SAS and SDS in Group A were significantly lower than in Group B（P〈0.05）. CONCLUSION： The FD of seamen was closely related to their psychological factors. Flupentixol Melitracen can improve the gastrointestinal symp- toms of seamen with FD and effectively keep the depression and anxiety disorder under control.