藏妇康栓对实验性阴道炎的治疗作用研究

目的:研究藏妇康栓对实验性阴道炎的治疗作用。方法:大鼠均分为6组,即正常对照、模型对照、达克宁栓(0.12g.kg-1)及藏妇康栓高、中、低剂量(0.33、0.17、0.08g(原生药).kg-1)组。采用白色念珠菌菌液注入人工动情期大鼠阴道复制大鼠霉菌性阴道炎模型,观察藏妇康栓对白色念珠菌感染率的影响;采用淋球菌-金黄色葡萄球菌-大肠杆菌混合菌液注入大鼠阴道复制大鼠细菌性阴道炎模型,观察藏妇康栓对大鼠淋球菌感染率影响。结果:藏妇康栓连续7d阴道局部给药,治疗大鼠霉菌性阴道炎,藏妇康栓高、中剂量组大鼠阴道分泌物白色念珠菌感染低于模型对照组(P<0.05)。藏妇康栓连续6d阴道局部给药,治疗大鼠细菌性阴道炎,藏妇康栓高、中剂量组大鼠阴道分泌物淋球菌阳性率低于模型对照组(P<0.05或P<0.01)。结论:藏妇康栓阴道局部给药,对大鼠霉菌性阴道炎和细菌性阴道炎均有显著治疗作用。

Therapeutical Effect of Zangfukang Suppository on Experimental Vaginitis in Rats

OBJECTIVE： To evaluate the therapeutic effect of Zangfukong suppository on the experimental vaginitis. METHODS： The experimental rats were equally assigned to 6 groups： normal control group, model control group, gyno- daktarin （0.12 g · kg^- 1） group, three Zangfukang groups （0.33 g,0.17,and 0.08 crude drug · kg ^-1） .Candida albicans solution was injected into the vigina of the estrous rats to establish colpomycosis model. The effect of Zangfukang suppository on the infection rate of candida albicans was observed. The bacterial vaginitis model was established by injecting the mixture bacteria of Neisseria gonorrhoeae, staphylococcus aureus and escherichia coli into the vagina of rats, and the effect of Zangfukang suppository on the gonococcal infection rate.RESULTS： After local application of Zangfukang suppository for 7 consecutive days for treatment of colpitis mycotica of rats, the infection rates of candida albicans were significantly lower in medium - dose and high - dose groups than in the model control group（P 〈 0.05） .After local application of Zangfukang suppository for 6 consecutive days for treatment of bacterial vaginitis, and the positive rates of neisseria gonorrhoeae in vaginal secretions in medium- dose and high- dose groups were significantly lower than in the model control group（P 〈 0.05 or P 〈 0.01） .CONCLUSION： Locally application of Zangfukang suppository showed remarkable therapeutic efficacy for both the experimental vaginal candidiasis and bacterial vaginitis of rats.