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江苏省血吸虫病监测预警关键技术研究与集成示范 II 5%杀螺胺颗粒剂大现场示范灭螺效果
引用本文:张正球,马玉才,孙乐平,高扬,陆宾,王福彪,张进,陈前,洪青标,汪伟,杨坤,梁幼生,戴建荣.江苏省血吸虫病监测预警关键技术研究与集成示范 II 5%杀螺胺颗粒剂大现场示范灭螺效果[J].中国血吸虫病防治杂志,2015,27(4):343.
作者姓名:张正球  马玉才  孙乐平  高扬  陆宾  王福彪  张进  陈前  洪青标  汪伟  杨坤  梁幼生  戴建荣
作者单位:1江苏省仪征市疾病预防控制中心 (仪征211400); 2江苏省扬州市邗江区疾病预防控制中心; 3江苏省血吸虫病防治研究所、 卫生部寄生虫病预防与控制技术重点实验室、 江苏省寄生虫分子生物学重点实验室; 4江苏省扬州市疾病预防控制中心
基金项目:国家科技重大专项 (2012ZX10004?220); 江苏省科技计划项目 (BL2014021); 江苏省科教兴卫工程高技术平台 (ZX201108); 江苏省卫生厅项目 (X201408、 X201410)
摘    要:目的 目的 通过现场试验获得5%杀螺胺颗粒剂现场应用的技术指标, 为血吸虫感染高危环境应急处置提供钉螺控制新技术。 方法 方法 在扬州市邗江区 (小现场) 和仪征市 (大现场) 各选择1个环境进行5%杀螺胺颗粒剂喷撒灭螺试验, 比较不同剂量、 不同时间和是否环境清障条件下的杀螺效果。 结果 结果 小现场试验显示, 30、 40、 50 g/m2 5%杀螺胺颗粒剂喷撒1、 3 d和7 d后, 钉螺死亡率分别为54.55%、 68.41%和73.45%, 57.27%、 68.59%和80.28%, 63.49%、 77.58%和85.55%; 其中30 g/m2 与40 g/m2 剂量组在喷撒后1、 3 d钉螺死亡率差异均无统计学意义 (P均 > 0.05), 喷撒后7 d钉螺死亡率差异有统计学意义 (χ2 = 4.549, P < 0.05), 40 g/m2 与50 g/m2 剂量组喷撒后1、 3 d和7 d钉螺死亡率差异均无统计学意义 (P均 > 0.05)。大现场试验显示, 未清障和清障环境采用40 g/m2 5%杀螺胺颗粒剂喷撒3、 7 d和15 d后钉螺死亡率分别为 85.29%、 83.89%、 83.41%和87.70%、 91.02%、 91.84%; 清障组喷撒后3~15 d钉螺总体死亡率为90.02%, 显著高于未清障组 (84.28%)(χ2 = 9.950, P < 0.05); 清障与未清障组喷撒15 d后活螺密度分别由19.90只/0.1 m2 和19.83只/0.1 m2 下降至0.60只/0.1 m2 和2.60只/0.1 m2 , 分别下降了96.98%和86.89%。 结论 结论 5%杀螺胺颗粒剂现场喷撒灭螺适宜剂量为40 g/m2 , 对环境中高于50 cm的植被清障将提高灭螺效果。

关 键 词:血吸虫病    钉螺    5%杀螺胺颗粒剂    灭螺效果    应急处置    效果评价    江苏省  

Integration and demonstration of key techniques in the surveillance and forecast of schistosomiasis in Jiangsu Province II Molluscicidal effect of 5% niclosamide ethanolamine granules in large-scale settings
ZHANG Zheng-Qiu,MA Yu-Cai,SUN Le-Ping,GAO Yang,LU Bin,WANG Fu-Biao,ZHANG Jin,CHEN Qian,HONG Qing-Biao,WANG Wei,YANG Kun,LIANG You-Sheng,DAI Jian-Rong.Integration and demonstration of key techniques in the surveillance and forecast of schistosomiasis in Jiangsu Province II Molluscicidal effect of 5% niclosamide ethanolamine granules in large-scale settings[J].Chinese Journal of Schistosomiasis Control,2015,27(4):343.
Authors:ZHANG Zheng-Qiu  MA Yu-Cai  SUN Le-Ping  GAO Yang  LU Bin  WANG Fu-Biao  ZHANG Jin  CHEN Qian  HONG Qing-Biao  WANG Wei  YANG Kun  LIANG You-Sheng  DAI Jian-Rong
Institution:1 Yizheng Center for Disease Control and Prevention| Jiangsu Province| Yizheng 211400| China; 2 Hanjiang District Center for Disease Control and Prevention| Yangzhou City| Jiangsu Province| China; 3 Jiangsu Institute of Parasitic Diseases| Key Laboratory on Technology for Parasitic Disease Prevention and Control| Ministry of Health| Jiangsu Provincial Key Laboratory on Molecular Biology of Parasites| China; 4 Yangzhou Municipal Center for Disease Control and Prevention| Jiangsu Province| China
Abstract:Objective Objective To evaluate the field molluscicidal effect of 5% niclosamide ethanolamine granules,so as to provide a novel Oncomelania hupensis snail control approach for emergency treatment of high?risk settings. Methods Methods Snail control tests with spraying of 5% niclosamide ethanolamine granules were conducted in two settings of 2 counties,and the dose?,time? and setting?specific field molluscicidal effects were tested. Results Results In the small?scale setting,spraying of 5% niclosamide ethanolamine granules at doses of 30,40 and 50 g/m2 resulted in 54.55%,68.41% and 73.45% 1?day snail mortality,57.27%,68.59% and 80.28% 3?day snail mortality,and 63.49%,77.58% and 85.55% 7?day snail mortality,respectively,and no significant dif? ferences were detected in 1? and 3?day snail mortality caused by spraying of 5% niclosamide ethanolamine granules at doses of 30 and 40 g/m2 (all P > 0.05),while significant difference was found in the 7?day snail mortality(χ2 = 4.549,P < 0.05) . In ad? dition,spraying of 5% niclosamide ethanolamine granules at doses of 40 and 50 g/m2 resulted in comparable 1?,3? and 7?day snail mortality(all P > 0.05) . In the large?scale setting,spraying of 5% niclosamide ethanolamine granules at a dose of 40 g/m2 resulted in 85.29% and 87.70% 3?day snail mortality,83.89% and 91.02% 7?day snail mortality,and 83.41% and 91.84% 15? day snail mortality in the environment ? cleaning group and non ? cleaning group,respectively. The overall snail mortality was 90.02% in the environment?cleaning group 3 to 15 days after spraying,which was significantly higher than that(84.28%)in the non?cleaning group(χ2 = 9.950,P < 0.05) . After 15 days of spraying with 5% niclosamide ethanolamine granules at a dose of 40 g/m2 ,the densities of living snails reduced from 19.90 and 19.83 snails/0.1 m2 to 0.60 and 2.60 snails/0.1 m2 in the environ? ment?cleaning group and non?cleaning group,with 96.98% and 86.89% reductions,respectively. Conclusion Conclusion The appropriate dose of 5% niclosamide ethanolamine granules is 40 g/m2 for snail control in the field,and environment cleaning of vegetation with a height of more than 50 cm may improve the molluscicidal efficacy.
Keywords:Schistosomiasis  Oncomelania snail  5% niclosamide ethanolamine granules  Molluscicidal efficacy  Emergen? cy treatment  Effect evaluation  Jiangsu Province  
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