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Treatment progress of Kawasakidisease at acutestage

??Abstract?? The incidence of Kawasaki disease??KD?? is increasing in Asian countries??even worldwide. Refractory cases still have a strong challenge. Incomplete KD and non-responders to initial IVIG treatment may increase the rate of the coronary artery lesions??CAL??. Because of the rate of resistance to initial IVIG treatment??timely additional treatment can significantly reduce the risk of echocardiologically defined CAL in the majority of patients. It’s important to diminish inflammation?? endothelial dysfunction and CAL formation??including application of tumor necrosis factor-alpha antagonist?? methylprednisolone pulse therapy??ulinastatin and cytotoxic agents??which helps to decrease the life-long sequelae of the cardiovascular lesions.