3种材质输液容器对氟尿嘧啶的吸附性考察

目的：考察非聚氯乙烯（NPVC）多层共挤膜输液袋、聚丙烯（PP）输液瓶和玻璃瓶3种材质输液容器对氟尿嘧啶的吸附性。方法：将一定量的氟尿嘧啶加入3种包装材质输液中，与输液混合均匀后分别于0，6，24，48h取样，采用高效液相色谱法测定药物浓度。结果：48h相对0h的药物含量百分数：①在PP输液瓶中，氟尿嘧啶含量在82．95％-94．9％之间；②在玻璃瓶中氟尿嘧啶含量在96．59％-101．26％之间；③在NPVC输液袋中氟尿嘧啶含量在98．30％～100．19％之间。结论：PP输液瓶对氟尿嘧啶有吸附性，临床使用该药时避免选用该材质输液瓶，若不能避免选用，应考虑适当增加剂量。

Study on Adsorbability of Fluorouracil in Three Different Kinds of Intravenous Solution Containers

Objective： To investigate the adsorbability of non-polyvinly chloride（NPVC） infusion bags, glass bottles（G） and poly-propylenc （PP） infusion bags to fluorouracil respectively. Method： Fluorouracil was separately added to above infusion bags or bottles containing intravenous solution. Samples of drug solutions were collected at 0,6,24,48 hours and analyzed by HPLC methods. Result： The contents of fluorouraeil in pp, G and NPVC within 48 hours were 82.95% -94.9% ,96.59% - 101.26% and 98.30 - 100.18% , respectively. Conclusion： PP should not be used with fluorouracil . If there are no other choices, addition of extra drug to compensate for the losses is suggested.