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| 当归精油对大鼠离体子宫平滑肌收缩的影响 | |
| 引用本文： | 刘琳娜,梅其炳,尚磊,程建峰,桑韩飞. 当归精油对大鼠离体子宫平滑肌收缩的影响[J]. 中成药, 2004, 26(4): 308-311 |
| 作者姓名： | 刘琳娜 梅其炳 尚磊 程建峰 桑韩飞 |
| 作者单位： | 1. 第四军医大学药理学教研室,陕西,西安,710032 2. 第四军医大学卫生统计学教研室,陕西,西安,710032 3. 第四军医大学唐都医院药剂科,陕西,西安,710038 |
| 摘 要： | 目的:观察当归精油对大鼠离体子宫平滑肌收缩的影响.方法:制作离体子宫平滑肌肌条,考察催产素、高钾去极化溶液存在条件下当归精油对子宫肌条反应的影响.结果:当归精油对催产素及高K 去极化液中Ca2 所致的离体子宫平滑肌收缩均呈剂量依赖性抑制;使CaCl2累积量-效曲线非平行性右移,最大效应下降,呈非竞争性抑制;且对子宫平滑肌依细胞内、外Ca2 两种收缩成分均呈抑制作用.结论:当归精油对大鼠离体子宫平滑肌条的抑制作用,可能与其拮抗Ca2 有关. |
| 关 键 词： | 当归 精油 维拉帕米 催产素 大鼠离体子宫 |
| 文章编号： | 1001-1528(2004)04-0308-03 |
Effects of essential oil from Radix Angelicae Sinensis on rat uterine contraction in vitro |
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| LIU Lin na,MEI Qi bing,SHANG Lei,CHENG Jian feng,SANG Han fei. Effects of essential oil from Radix Angelicae Sinensis on rat uterine contraction in vitro[J]. Chinese Traditional Patent Medicine, 2004, 26(4): 308-311 | |
| Authors: | LIU Lin na MEI Qi bing SHANG Lei CHENG Jian feng SANG Han fei |
| Abstract: | AIM: To investigate the contraction effect of essential oil of Radix Angelicae Sinensis on isolated uterus in rats. METHODS: Isolated uterine strips of rats were used to observe the reactions in the presence of oxytocine and high k depolarization solution. RESULTS: The isolated rat uterus contraction induced by oxytocin and Ca 2 after high K depolarization was dose dependently inhibited by the essential oil. The cumulative dose response curves of CaCl 2 shifted to right and the maximal responses were depressed. This showed that the essential oil was a non competitive antagonist. The extracellular and intracellular Ca 2 dependent contraction evoked by oxytocin could also be inhibited by the essential oil. CONCLUSION: The essential oil of Radix Angelicae Sinensis could inhibit the contractility of the isolated uteri, and it might act as an Ca 2 antagonist to relax the isolated rat uterus. |
| Keywords: | Radix Angelicae Sinensis essential oil oxytocin isolated rat uterus |
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