| 乳腺癌患者血清抵抗素、脂联素和瘦素水平及其临床意义 |
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| 引用本文： | 范杰,刘冰,曹文艳,高卫国. 乳腺癌患者血清抵抗素、脂联素和瘦素水平及其临床意义[J]. 上海医学检验杂志, 2011, 0(1) |
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| 作者姓名： | 范杰 刘冰 曹文艳 高卫国 |
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| 作者单位： | 河北工程大学附属医院检验科;邯郸市第一医院外科;秦皇岛市中医院检验科; |
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| 摘 要： | 目的了解乳腺癌患者血清中抵抗素、脂联素、瘦素及血脂变化及临床意义。方法测定90例乳腺癌患者(48例未绝经,42例已绝经)及50名健康对照者血清抵抗素、脂联素、瘦素、空腹血糖(FBG)及血脂。结果乳腺癌患者脂联素及高密度脂蛋白胆固醇(HDL-C)显著低于对照组(P<0.01或P<0.05),抵抗素、瘦素、FBG及三酰甘油(TG)均明显增加(P<0.01或P<0.05)。但抵抗素、脂联素及瘦素在未绝经乳腺癌患者与健康对照组之间差异无统计学意义(P>0.05)。有淋巴结转移的乳腺癌患者抵抗素、脂联素及瘦素水平与无淋巴结转移乳腺癌患者间差异有统计学意义(P<0.01)。逐步回归分析,脂联素及HDL-C的降低,瘦素和抵抗素的升高将会增加罹患乳腺癌的风险。血清脂联素降低和瘦素的增加与乳腺癌患者淋巴结的转移呈现相关性。结论血清脂联素水平的降低和抵抗素及瘦素水平的升高是患乳腺癌的危险因素。血清中较低的脂联素和较高的瘦素水平是乳腺癌转移的危险因素。
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| 关 键 词： | 脂联素 抵抗素 瘦素 脂肪细胞因子 乳腺癌 |
Serum levels of resistin,adiponectin and leptin in breast cancer patients and its clinical significance |
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| FAN Jie,LIU Bing,CAO Wenyan,GAO Weiguo.. Serum levels of resistin,adiponectin and leptin in breast cancer patients and its clinical significance[J]. Shanghai Journal of Medical Laboratory Sciences, 2011, 0(1) |
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| Authors: | FAN Jie LIU Bing CAO Wenyan GAO Weiguo. |
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| Affiliation: | FAN Jie1,LIU Bing2,CAO Wenyan3,GAO Weiguo1.(1.Department of Clinical Laboratory,the Affiliated Hospital of Hebei University of Engineering,Hebei Handan 056029,China,2.Department of Surgery,Handan First Hospital,3.Qinhuangdao Hospital of Traditional Chinese Medicine,Hebei Qinhuangdao 066000,China) |
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| Abstract: | Objective To investigate the change of serum levels of resistin,adiponectin and leptin in breast cancer patients and its clinical significance.Methods Blood samples were collected from 90 breast cancer patients(48 non-menopausal women and 42 menopausal women) and 50 healthy controls.Serum levels of resistin,adiponectin and leptin were determined.Fasting blood glucose(FBG) and blood lipids were assayed simultaneously.Results Serum levels of adiponectin and high-density lipoprotein cholesterol(HDL-C) were sig... |
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| Keywords: | Adiponectin Resistin Leptin Adipocytokines Breast cancer |
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