| 脂蛋白相关磷脂酶A2在冠心病患者严重程度评估中的应用 |
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| 引用本文： | 邬建民,张力.脂蛋白相关磷脂酶A2在冠心病患者严重程度评估中的应用[J].上海医学检验杂志,2011(2). |
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| 作者姓名： | 邬建民 张力 |
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| 作者单位： | 上海市杨浦区精神卫生中心检验科;上海交通大学医学院附属新华医院检验科; |
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| 摘 要： | 目的评估脂蛋白相关磷脂酶A2(Lp-PLA2)在冠心病患者严重程度评估及远期心血管事件发生预测中的价值。方法将165例因胸痛行冠状动脉造影的患者按造影结果分为冠心病组98例其中稳定性心绞痛(SAP)患者59例、急性冠状动脉综合症(ACS)患者39例]和非冠心病组67例。冠心病组按照病变累及的冠状动脉支数分为单支、二支和三支组,同时对每位冠心病患者进行Gensini评分。检测所有患者入院后24 h内的血浆Lp-PLA2及总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)水平。随访1～2年,记录主要不良心血管事件。分析不同病例组别、不同病变支数和有、无发生主要不良心血管事件患者的Lp-PLA2水平差异。结果冠心病患者Lp-PLA2水平明显高于非冠心病组(P<0.01),ACS患者Lp-PLA2水平高于SAP患者(P<0.05)。冠心病组TC和LDL-C水平与非冠心病组比较均无差异。冠心病三支病变组Lp-PLA2水平明显高于单支和二支病变组(P<0.01、P<0.05),而单支、二支病变组间无差异(P>0.05)。不良心血管事件阳性患者Lp-PLA2水平明显高于阴性患者(P<0.01)。结论 Lp-PLA2可用于...
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| 关 键 词： | 脂蛋白相关磷脂酶A2 冠心病 不良心血管事件 危险因子 |
The application of plasma Lp-PLA2 determination in the severity evaluation among the patients with coronary artery disease |
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| WU Jianmin,ZHANG Li..The application of plasma Lp-PLA2 determination in the severity evaluation among the patients with coronary artery disease[J].Shanghai Journal of Medical Laboratory Sciences,2011(2). |
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| Authors: | WU Jianmin ZHANG Li |
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| Institution: | WU Jianmin1,ZHANG Li2.(1.Department of Clinical Laboratory,Yangpu District Mental Health Center,Shanghai 200090,China,2.Department of Clinical Laboratory,Xinhua Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200092,China) |
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| Abstract: | Objective To evaluate the predictive value of lipoprotein-associated phospholipase A2(Lp-PLA2) in the severity evaluation and future cardiovascular events among the patients with coronary artery disease(CAD).Methods 165 chest pain patients were enrolled and administrated coronary artery angiography.The patients were classified into stable angina pectoris(SAP) group(59 patients),acute coronary syndrome(ACS) group(39 patients) and non-coronary artery disease group(67 patients) according to the angiography res... |
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| Keywords: | Lipoprotein-associated phospholipase A2 Coronary artery disease Adverse cardiovascular event Risk factor |
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