| 羟苯磺酸钙联合缬沙坦对老年早期糖尿病肾病患者血清内皮素和胱抑素C的影响 |
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| 引用本文： | 季中秋. 羟苯磺酸钙联合缬沙坦对老年早期糖尿病肾病患者血清内皮素和胱抑素C的影响[J]. 实用临床医药杂志, 2015, 19(1): 39-41 |
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| 作者姓名： | 季中秋 |
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| 作者单位： | 江苏省盐城市第三人民医院药学科,江苏盐城,224000 |
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| 摘 要： | 目的观察羟苯磺酸钙联合缬沙坦对老年早期糖尿病肾病(DN)患者血清内皮素(ET)和胱抑素C(Cys C)的影响。方法 100例老年早期DN患者随机分为羟苯磺酸钙组30例,缬沙坦组33例,联合组37例,分别给予羟苯磺酸钙、缬沙坦单药治疗和联合治疗12周。结果联合组有效率显著高于羟苯磺酸钙组与缬沙坦组(P0.05);3组治疗后血肌酐(Scr)、尿素氮(BUN)、尿蛋白排泄量(UAE)和血清ET、Cys C水平均较治疗前显著降低(P0.05或P0.01),且联合组显著低于羟苯磺酸钙组和缬沙坦组(P0.05)。结论羟苯磺酸钙和缬沙坦联合用药治疗老年早期DN疗效优于单药治疗,可更有效降低血清ET、Cys C水平,改善肾功能。
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| 关 键 词： | 糖尿病肾病 羟苯磺酸钙 缬沙坦 内皮素 胱抑素C |
Influence of calcium dobesilate combined with valsartan on serum endothelin and cystatin C level in elderly patients with early diabetic nephropathy |
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| JI Zhongqiu. Influence of calcium dobesilate combined with valsartan on serum endothelin and cystatin C level in elderly patients with early diabetic nephropathy[J]. Journal of Clinical Medicine in Practice, 2015, 19(1): 39-41 |
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| Authors: | JI Zhongqiu |
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| Affiliation: | JI Zhongqiu;Department of Pharmacy,Yancheng Third People’s Hospital; |
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| Abstract: | |
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| Keywords: | diabetic nephropathy calcium dobesilate valsartan endothelin cystatin C |
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