炎康颗粒的抗炎作用及机制研究

目的研究炎康颗粒的抗炎作用，并探讨其作用机制。方法采用巴豆油致小鼠耳肿胀实验模型、角叉菜胶致雄性大鼠足跖肿胀实验模型，观察炎康颗粒对急性炎症的作用；采用大鼠棉球肉芽肿实验模型，观察炎康颗粒对慢性炎症的作用；采用摘除双侧肾上腺的大鼠进行角叉菜胶致足跖肿胀实验及棉球肉芽肿实验，以观察炎康颗粒抗炎作用与下丘脑-垂体-肾上腺轴（HPAA）的关系。结果炎康颗粒8、16g（生药）／kg连续给药1周，明显抑制小鼠耳肿胀；1.8g（生药）／kg明显抑制由角叉菜胶诱导的大鼠足趾肿胀；明显抑制大鼠棉球肉芽的增生。摘除肾上腺后，炎康颗粒连续给药1周，无明显抗炎作用。结论炎康颗粒对急性炎症和慢性炎症均有明显的防治作用，其抗炎作用依赖于HPAA系统，并与减少白细胞介素有关。

Anti-inflammatory effect and mechanism of Yankang Particles

Objective To investigate the anti-inflammatory effecet and its mechanism of Yankang Particles. Methods For the sake of observing the effect of Yankang Particles on acute inflammation,the model of mice ear swelling was induced by crotonic oil;the model of rat paw edema was induced by earrageenin. The model of rat cotton pellet granuloma were used to analyse Yankang Particles the effect on chronic inflammation. The models of carrageenin induced paw edema,and cotton pellet granuloma in rat with bilateral adrenalectomized were used to investigate the relationship between the anti-inflammatory effect of Yankang Particles and hypothalamus-pituitary-adrenal axis （HPAA）. Results Yankang Particles 8,16 g （crude drug）/kg can significantly inhibited carrageenin-induced rat paw edema after successive administration for l week, 4, 8 g （crude drug）/kg were capable of inhibit cotton pellet granuloma hyperplasia after successive administration for 1 week. After were adrenalectomized in rats and successive administration for 1 week, there＇s no obrvious anti-inflammatory effect. Conclusion The experiments demonstrated the prevention and treatment of Yankang Particles of acute and chronic inflammation, and its anti-inflammatory effect dependent on HPAA system,and is associated with decreasing of IL-1β.