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| 宫颈癌组织血管内皮生长因子测定的临床意义 | |
| 引用本文： | 刘乃富,王兴武,马悦冰,李庆水,盛修贵,于金明.宫颈癌组织血管内皮生长因子测定的临床意义[J].中华肿瘤防治杂志,2004,11(2):139-141. |
| 作者姓名： | 刘乃富 王兴武 马悦冰 李庆水 盛修贵 于金明 |
| 作者单位： | 1. 山东大学齐鲁医院妇产科,山东,济南,250012 2. 山东省肿瘤医院基础研究中心,山东,济南,250117 3. 山东省肿瘤医院妇瘤科,山东,济南,250117 4. 山东省肿瘤医院放疗科,山东,济南,250117 |
| 摘 要： | 目的 :探讨血管内皮生长因子 (vascularen dothelialgrowthfactor ,VEGF)在宫颈癌诊断、治疗以及转移中的临床意义。方法 :酶联免疫吸附分析法(enzyme linkedimmunosorbentassay ,ELISA)测定 2 0例宫颈上皮内瘤样变患者和 60例宫颈癌患者组织中的VEGF含量。结果 :VEGF含量在宫颈上皮内瘤样变、宫颈癌组织中分别为 5 5 6pg/mg、410 2pg/mg ,差异有统计学意义 ,P <0 0 1。肿 瘤≥ 4cm者为 960 0 pg/mg ,淋巴结转移者为 780 5 pg/mg ,而肿瘤 <4cm者 ,淋巴结未转移者分别为 180 5 pg/mg、2 3 0 0pg/mg。差异有统计学意义 ,P <0 0 5。而在临床分期、病理分型、病理分级间差异无统计学意义。结论 :组织VEGF含量检测对宫颈癌的诊断有一定的临床价值 ,其含量变化可监测宫颈癌的转移。 |
| 关 键 词： | 内皮生长因子 宫颈肿瘤 肿瘤标记 生物学 |
| 文章编号： | 1009-4571(2004)02-0139-03 |
| 修稿时间： | 2003年7月10日 |
Significance of vascular endothelial growth factor in cervical cancer |
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| LIU Nai fu ,WANG Xing wu ,MA Yue bing ,LI Qing shui ,SHENG Xiu gui ,YU Jin ming.Significance of vascular endothelial growth factor in cervical cancer[J].Chinese Journal of Cancer Prevention and Treatment,2004,11(2):139-141. | |
| Authors: | LIU Nai fu WANG Xing wu MA Yue bing LI Qing shui SHENG Xiu gui YU Jin ming |
| Institution: | LIU Nai fu 1,WANG Xing wu 2,MA Yue bing 2,LI Qing shui 2,SHENG Xiu gui 2,YU Jin ming 2 1.Department of Gynecological Onclogy,Qilu Hospital of Shandong University,Jinan 250012,P.R.China 2.Department of Gynecological Oncology,Shandong Tumor Hospital,Jinan 250117,P.R.China |
| Abstract: | OBJECTIVE:To study the clinical significance of vascular endothelial growth factor (VEGF) on diagnosis, treatment and metastasis in cervical cancer.METHODS:VEGF protein level in 60 cervical cancer tissues and in 20 cervical erosion tissues were measured by enzyme linked immunosorbent assay (ELISA).RESULTS:The median concentrations of VEGF in cervical cancer tissues (410 2 pg/mg) were higher than those in cervical erosion tissues (55 6 pg/mg), P <0 01. Higher levels were also found in tumors larger than 4 cm and pelvic lymph node metastasis, P <0 05, whereas there was no significant difference with the stage,histological type, histological grade, P >0 05.CONCLUSIONS:Tissue VEGF protein level may be a useful marker for cervical cancer diagnosis and may be used as a predictor of lymph node metastasis. |
| Keywords: | vascular endothelial growth factor (VEGF) cervical neoplasm tumor markers biological |
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