| 复方利多卡因乳膏外用安全性试验 |
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| 引用本文： | 朱亚丽,盛国荣.复方利多卡因乳膏外用安全性试验[J].药学与临床研究,2011,19(5):475-477. |
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| 作者姓名： | 朱亚丽 盛国荣 |
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| 作者单位： | 1. 南通体臣卫生学校药学教研室,南通,226007
2. 南通市皮肤病性病防治所,南通,226006 |
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| 摘 要： | 目的:对复方利多卡因乳膏进行了动物实验研究,包括皮肤急性毒性试验,皮肤过敏性试验和皮肤刺激性试验,以了解其安全性。方法:将不同剂量的复方利多卡因乳膏用于白色豚鼠背部正常和破损去毛区皮肤,观察其产生急性毒性情况;采用致敏与激发接触复方利多卡因乳膏,观察动物过敏情况;以一次给药和多次给药方法,将复方利多卡因乳膏外涂于白色豚鼠背部正常和破损去毛区皮肤,观察其产生豚鼠皮肤刺激性反应。结果:复方利多卡因乳膏未产生急性毒性反应,反复致敏后使用也无皮肤与全身过敏反应,一次或多次给药的刺激性强度对豚鼠正常皮肤平均反应分值均低于0.5分,对破损皮肤平均反应分值在给药后24 h和48h高于0.5分,但低于2.99分,48 h或72 h后平均反应分值均低于0.5分。结论:外用复方利多卡因乳膏未产生急性毒性和过敏反应,对豚鼠正常皮肤无刺激性,对破损皮肤有轻度刺激性,但给药后48 h或72 h,这种刺激性消失。
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| 关 键 词： | 复方利多卡因乳膏 皮肤 急性毒性试验 过敏反应 刺激性试验 |
| 收稿时间： | 2011/2/15 0:00:00 |
| 修稿时间： | 2011/9/13 0:00:00 |
Safety Studies of External Compound Lidocaine Cream |
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| ZHU Ya-li and SHENG Guo-rong.Safety Studies of External Compound Lidocaine Cream[J].Pharmacertical and Clinical Research,2011,19(5):475-477. |
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| Authors: | ZHU Ya-li and SHENG Guo-rong |
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| Institution: | ZHU Ya-li1,SHENG Guo-rong2 1Pharmacy Department of Nantong Tichen Medical School,Nantong 226007,2Nantong Institute for Skin Disease Control and Prevention,Nantong 226006,China |
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| Abstract: | Objective: To research the safety of Compound Lidocaine Cream(CLC) by doing a series of animal tests on skin acute toxicity,allergy and irritation.Methods: Smearing different doses of CLC on the normal and damaged back skin of white Guinea pigs,the acute toxicity reactions of CLC were observed;using the methods of contact sensitization and excitation,its skin allergy reactions were observed;Smearing CLC once and multiple-time,its skin irritation reactions were observded.Results: CLC resulted in no acute tox... |
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| Keywords: | Compound Lidocaine Cream Skin Acute toxicity test Allergy reaction Irritation test |
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