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| 肿瘤浸润调节性T细胞生物学特性及调节性T细胞在肿瘤免疫治疗中的应用 | |
| 引用本文： | 倪红波,冯辉. 肿瘤浸润调节性T细胞生物学特性及调节性T细胞在肿瘤免疫治疗中的应用[J]. 肿瘤研究与临床, 2021, 0(5): 397-400 |
| 作者姓名： | 倪红波 冯辉 |
| 基金项目： | China Medical University, CMU, (00206, 201910159141) |
| 摘 要： | 调节性T细胞（Treg细胞）对机体内环境稳定至关重要。然而，肿瘤浸润Treg细胞（TITR）在肿瘤微环境（TME）中发挥免疫抑制作用，削弱抗肿瘤特异性免疫应答，从而促进肿瘤逃避免疫监视。近来，随着免疫检查点抑制剂、趋化因子及其受体阻断剂、Treg细胞选择性靶点敲除和新药的问世，基于Treg细胞的肿瘤免疫治疗取得了较好的... |
| 关 键 词： | 调节性T细胞 肿瘤微环境 免疫疗法 |
Biological characteristics of tumor infiltrating regulatory T cells and the application of regulatory T cells in tumor immunotherapy |
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| Affiliation: | 1.Department of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang110122; |
| Abstract: | Regulatory T cells (Treg cells) have a critical role in the maintenance of immune homeostasis. However, tumor infiltrating Treg (TITR) contributes to weaken anti - tumor specific immune response through enhancing immunosuppressive effect in tumor microenvironment (TME), leading to tumor escape from immune surveillance. Recently, Treg cells-based immunotherapy has achieved good anti-tumor effects with the appearance of immune checkpoint inhibitors, chemokines and their receptors antagonists, specific Treg cells selective target genes knockout and novel drugs. This paper reviews the biological characteristics of TITR and discusses the prospect and application of Treg cells-based immunotherapy. © 2021 Chinese Medical Association Publishing House Co. Ltd. All rights reserved. |
| Keywords: | Immunotherapy Regulatory T cells Tumor microenvironment |
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