康艾注射液联合DP方案治疗老年中晚期非小细胞肺癌近期效果及对患者免疫功能影响

目的 探讨康艾注射液联合DP方案治疗老年中晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)的近期效果及对免疫功能的影响.方法 选取老年中晚期NSCLC 94例,根据治疗方法 不同将其分为观察组(49例)和对照组(45例)两组.观察组采用康艾注射液联合DP方案(顺铂联合吉西他滨)治疗,...

Short-term Effect of Kang'ai Injection Combined with DP Regimen in the Treatment of Elderly Patients with Advanced Non-small Cell Lung Cancer and Its Influence on Immune Function

Objective To investigate the short-term effect of Kang'ai injection combined with DP regimen in the treatment of elderly patients with advanced non-small cell lung cancer(NSCLC)and its influence on immune function.Methods Ninety-four elderly patients with advanced NSCLC were selected and divided into observation group(n=49)and control group(n=45)according to different treatment methods.The observation group was treated with Kang'ai injection combined with DP regimen(Cisplatin combined with Gemcitabine),while the control group was treated with DP regimen for 4 consecutive cycles.The short-term effect after treatment,serum immune indexes and soluble interleukin-2 receptor(SIL-2R)before and after treatment,as well as the incidence of adverse reactions during the treatment were observed and compared between the two groups.Results After treatment,the short-term total effective rate of the observation group was 85.71%,which was significantly higher than that of the control group(64.44%)(P<0.05).Before treatment,there was no significant difference in serum immune index and SIL-2R level between the two groups(P>0.05).After treatment,the levels of serum IgG,IgA,IgM and serum CD3+,CD4+in the two groups were higher than those before treatment,while the levels of IgG,IgA,IgM in the control group and the levels of CD8+,SIL-2R in the two groups were lower than those before treatment(P<0.05 or P<0.01).After treatment,the levels of serum IgG,IgA,IgM,CD3+,CD4+in the observation group were higher than those in the control group,while the serum CD8+and SIL-2R levels were lower in the observation group than in the control group(P<0.01).During the treatment,the incidence of liver injury and myelosuppression in the observation group was significantly lower than that in the control group(P<0.05).Conclusion Kang'ai injection combined with DP regimen in the treatment of elderly patients with advanced NSCLC can improve the short-term effect,improve the immune function and reduce the toxic and side effects of chemotherapy.