脑炎后癫痫持续状态进展为难治性癫痫持续状态及超级难治性癫痫持续状态的早期预测因素

目的 探讨脑炎后癫痫持续状态(SE)进展为难治性SE(RSE)及超级RSE(SRSE)的早期预测因素.方法 根据疾病进展情况将89例脑炎后SE患者分为非RSE组、RSE组及SRSE组.比较各组临床资料.结果 非RSE组、RSE组及SRSE组年龄、SE严重程度评分量表(STESS)评分、基于流行病学SE病死率评分(EMS...

Early predictive factor of status epilepticus progressed to refractory status epilepticus and persistent state of super-refractory epilepsy after encephalitis

Objective To explore the early predictive factor of status epilepticus(SE) progressed to refractory status epilepticus(RSE) and super-RSE(SRSE) after encephalitis. Methods According to the disease progression, 89 SE patients were dividing into non-RSE group, RSE group and SRSE group. The clinical data of three groups were compared. Results Age, status epilepticus severity score(STESS), epidemiology-based mortality score in status epilepticus(EMSE) score, encephalitis-nonconvulsive status epilepticus(NCSE)-diazepam resistance-image abnormalities-tracheal intubation(END-IT) score, GCS score, acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ) score and the rates of imaging features, NCSE in coma, resistance to benzodiazepines, withdrawal seizures, tracheal intubation, application of active drug of blood vessel in non-RSE group, RSE group and SRSE group had statistical significance(P<0.05-0.01). Logistic regression analysis showed that EMSE score≥42.5(OR=1.176, 95%CI:0.984-1.405, P=0.075), withdrawal seizures(OR=10.164, 95%CI:1.825-56.603, P=0.008) and NCSE in coma(OR=7.577, 95%CI:1.337-42.940, P=0.022) were predictive factors of SE progressed to RSE and SRSE. Conclusion EMSE, withdrawal seizures and NCSE in coma are early predictive factors of SE progressed to RSE and SRSE.