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| P38MAPK信号通路在糖尿病肾脏病研究中的进展 | |
| 引用本文： | 马冬妹,张祥贵. P38MAPK信号通路在糖尿病肾脏病研究中的进展[J]. 临床肾脏病杂志, 2021, 21(3): 248-253 |
| 作者姓名： | 马冬妹 张祥贵 |
| 作者单位： | 遵义医科大学第五附属(珠海)医院肾内科 519100 |
| 基金项目： | 贵州省卫生和计划生育委员会科学技术基金资助项目(gzwjkj2017-1-025)。 |
| 摘 要： | 糖尿病肾脏病是糖尿病最严重的慢性并发症之一,是导致慢性肾衰的主要病因,P38MAPK是MAPK信号通路中重要的信号转导分子,是细胞信号传递的交汇点和共同通路.p38MAPK信号转导通路可通过增加活性氧类的产生增加炎性介质的释放,调节肾素-血管紧张素系统,影响肾小球系膜外基质的形成与降解,从而加速糖尿病肾脏病进程,以p3... |
| 关 键 词： | 糖尿病肾脏病 P38MAPK p38MAPK抑制剂 中药 |
Recent advances of P38MAPK signaling pathway in diabetic nephropathy |
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| Ma Dong-mei,Zhang Xiang-gui. Recent advances of P38MAPK signaling pathway in diabetic nephropathy[J]. Journal Of Clinical Nephrology, 2021, 21(3): 248-253 | |
| Authors: | Ma Dong-mei Zhang Xiang-gui |
| Affiliation: | (Department of Nephrology,Fifth Affiliated(Zhuhai)Hospital,Zunyi Medical University,Zhuhai 519100,China) |
| Abstract: | As one of the most serious chronic complications of diabetes,diabetic nephropathy is a major cause of chronic renal failure.P38MAPK is an important signal transduction molecule in MAPK signal pathway.It accelerates the process of diabetic nephropathy by stimulating the production of reactive oxygen species,boosting the release of inflammatory mediators,regulating renin-angiotensin system and affecting the formation and degradation of glomerular mesangial matrix.And p38MAPK inhibitor and traditional Chinese medicine with p38MAPK as therapeutic target are expected to become new pharmaceutical preparations for diabetic nephropathy. |
| Keywords: | Diabetic nephropathy P38 MAPK P38 MAPK inhibitor Traditional Chinese medicine |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |