CT双输入模型低剂量容积灌注成像对肺孤立性炎性假瘤的诊断价值

目的 探讨CT双输入模型低剂量容积灌注成像对肺孤立性炎性假瘤的诊断价值.方法 选取经手术或穿刺病理检查证实的肺孤立性、直径范围2.0～5.0 cm炎性假瘤22例和周围型肺癌38例,均行CT双输入模型低剂量容积灌注成像,分析肺孤立性炎性假瘤和周围型肺癌血供情况,比较二者强化达峰时间(TTP)和灌注参数肺动脉血流量(PF)...

Value of Dual-Input Volume CT Low-Dose Perfusion Imaging in the Diagnosis of Isolated Lung Inflammatory Pseudotumor

Objective To evaluate the diagnositic value of the dual-input volume CT low-dose perfusion imaging in isolated lung inflammatory pseudotumor of the lung(IPL).Methods All isolated pulmonary nodules with a diameter range of 2.0-5.0 cm confirmed by pathology or puncture pathology(22 cases of inflammatory pseudotumor and 38 cases of peripheral lung cancer)were analyzed by dual-input volume CT low-dose perfusion imaging.The blood supply of inflammatory pseudotumor and peripheral lung cancer was analyzed,respectivley.Time to peak enhancement(TTP),and the perfusion index pulmonary flow(PF),bronchial flow(BF)and perfusion index(PI)were compared.The receiver operating characteristic(ROC)curve was used to analyze the value of TTP and perfusion indexs in differential diagnosis of inflammatory pseudotumor and peripheral lung cancer.Results The inflammatory pseudotumor was supplied by the balanced pulmonary artery and bronchial artery,and there was no significant difference in PF(50.71±19.02)ml/min and BF(42.13±21.27)ml/min(P>0.05).The PI was(44.04±10.49)%.Peripheral lung cancer was supplied by both pulmonary artery and bronchial artery,the PF(68.67±34.75)ml/min was higher than BF(48.26±24.31)ml/min(P<0.05)and the PI was(54.50±15.74)%.The TTP of isolated inflammatory pseudotumor was significantly lower than that of peripheral lung cancer,and the PF and PI were also lower than those of peripheral lung cancer(P<0.05 or P<0.01).The area under curve(AUC)of TTP was 0.93 for differential diagnosis of solitary inflammatory pseudotumor and peripheral lung cancer,which had a higher diagnostic value.When TTP=18.06 s was used as the cut-off value for predicting benign and malignant nodules,the sensitivity and specificity were 97.6%and 92.3%respectively.The AUC of PF and PI for differential diagnosis of solitary inflammatory pseudotumor and peripheral lung cancer was 0.71 and 0.70 respectively,showing a moderate diagnostic value.Conclusion TTP of dual-input volume CT low-dose perfusion imaging was helpful to improve the differential diagnosis between inflammatory pseudotumor and peripheral lung cancer.