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| 阻塞性睡眠呼吸暂停对非酒精性脂肪性肝病的影响 | |
| 引用本文： | 许青青,唐海英,毛靖伟. 阻塞性睡眠呼吸暂停对非酒精性脂肪性肝病的影响[J]. 临床肝胆病杂志, 2021, 0(1): 192-195 |
| 作者姓名： | 许青青 唐海英 毛靖伟 |
| 作者单位： | 大连医科大学附属第一医院消化内科;大连医科大学附属第一医院呼吸睡眠诊疗中心 |
| 基金项目： | 国家自然科学基金资助项目(81500402)。 |
| 摘 要： | 阻塞性睡眠呼吸暂停(OSA)引起机体长期处于慢性间歇性缺氧可导致多系统、多器官病变,严重者可发生心源性猝死。除合并呼吸、心脑血管、内分泌代谢等疾病外,OSA与消化系统疾病中的非酒精性脂肪性肝病(NAFLD)也有密切关联。简述了OSA和NAFLD的现状,叙述了OSA对NAFLD的影响,归纳了OSA影响NAFLD的机制,提出通过探索OSA影响NAFLD的可能机制,从OSA角度为NAFLD寻找新的潜在防治靶点,对延缓、甚至阻断NAFLD进展具有重要意义。 |
| 关 键 词： | 睡眠呼吸暂停,阻塞性 非酒精性脂肪性肝病 低氧 |
Impact of obstructive sleep apnea on nonalcoholic fatty liver disease |
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| XU Qingqing,TANG Haiying,MAO Jingwei. Impact of obstructive sleep apnea on nonalcoholic fatty liver disease[J]. Chinese Journal of Clinical Hepatology, 2021, 0(1): 192-195 | |
| Authors: | XU Qingqing TANG Haiying MAO Jingwei |
| Affiliation: | (Department of Gastroenterology,The First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning 116011,China;Respiratory and Sleep Clinic,The First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning 116011,China) |
| Abstract: | Obstructive sleep apnea(OSA)may induce chronic intermittent hypoxia,which may lead to the disorders of multiple systems and organs and even sudden cardiac death in severe cases.Besides respiratory,cardiovascular,endocrine,and metabolic diseases,OSA is also closely associated with nonalcoholic fatty liver disease(NAFLD).This article briefly describes the current status of OSA and NAFLD,introduces the impact of OSA on NAFLD,and reviews the mechanisms of OSA in NAFLD.It is pointed out that clarifying the mechanisms of OSA in affecting NAFLD and discovering potential prevention and treatment targets for NAFLD from the aspect of OSA are of great significance in delaying and even blocking the progression of NAFLD. |
| Keywords: | Sleep Apnea,Obstructive Non-alcoholic Fatty Liver Disease Hypoxia |
| 本文献已被 CNKI 维普 等数据库收录！ | |