血清Apelin-13、可溶性血栓调节蛋白、锁链素对急性肺栓塞患者病情及预后的评估价值

目的 探究血清脂肪细胞因子13(Apelin-13)、可溶性血栓调节蛋白(sTM)、锁链素(DES)对急性肺栓塞(APE)患者病情及预后的评估价值.方法 选取我院2017年10月～2019年8月APE患者118例作为观察组,另选取同期健康体检者115例作为对照组.于两组入院时检测血清Apelin-13、sTM、DES水...

Value of serum Apelin-13,soluble thrombomodulin,and desmosine in the assessment of disease and prognosis of patients with acute pulmonary embolism

Objective To investigate the value of serum adipokine 13(Apelin-13),soluble thrombomodulin(sTM),and desmosine(DES)in the evaluation of the condition and prognosis of patients with acute pulmonary embolism(APE).Methods From October 2017 to August 2019,118 patients with APE in our hospital were selected as the observation group,and 115 patients with healthy physical examination during the same period were selected as the control group.Serum Apelin-13,sTM,and DES levels were measured at the time of admission between the two groups,and the serum Apelin-13,sTM,and DES levels were compared between the two groups and patients with different disease degrees and different prognosis,and analyzed their correlation with the degree of disease.ROC curve was used to evaluate the prognostic value of serum Apelin-13,sTM,and DES,and Kaplan-Meier(KM)curve was used for survival analysis.Results The levels of serum Apelin-13,sTM and DES in the observation group were higher than those in the control group(P<0.05).Serum Apelin-13,sTM,and DES levels increased with the increase of disease severity(P<0.05).Spearman correlation analysis showed that serum Apelin-13(r=0.402),sTM(r=0.353),and DES(r=0.507)were positively correlated with disease severity(P<0.05).The serum levels of Apelin-13,sTM and DES at admission was higher in the death group than in the survival group(P<0.05).Logistic regression showed that serum Apelin-13,sTM and DES were significant prognostic factors(P<0.05).The AUC of serum Apelin-13,sTM,and DES combined for predicting prognosis was the highest(0.895),followed by DES(0.807),Apelin-13(0.728),and sTM(0.717),with a sensitivity of 80.00%and specificity of 87.18%.KM curve analysis showed that the survival rate of those with high expression of serum Apelin-13,sTM and DES was lower than that of those with low expression(P<0.05).Conclusion Serum Apelin-13,sTM and DES are closely related to the severity of APE,which is helpful to predict the prognosis and survival status,and provide a reliable reference for clinical diagnosis and treatment.