| 急性缺血性脑血管病药物性脑保护的研究进展 |
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| 引用本文： | 彭静玉,李光来. 急性缺血性脑血管病药物性脑保护的研究进展[J]. 中西医结合心脑血管病杂志, 2005, 3(8): 722-724 |
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| 作者姓名： | 彭静玉 李光来 |
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| 作者单位： | 山西医科大学第二医院 |
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| 摘 要： | 兴奋毒性、钙超载、自由基反应、梗死周围除极、炎症和凋亡是造成缺血性脑损伤的中心环节.脑保护是治疗急性缺血性脑血管病的主要策略之一.处于临床研究阶段的脑保护剂有钙通道拮抗剂、兴奋性氨基酸受体拮抗剂、γ-氨基丁酸受体激动剂、抗氧化剂和自由基清除剂等等.
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| 关 键 词： | 急性缺血性脑血管病 脑保护 钙通道拮抗剂 |
| 文章编号： | 1672-1349(2005)08-0722-03 |
| 收稿时间： | 2005-05-24 |
| 修稿时间： | 2005-05-24 |
Progress in Research on Neuroprotective Agents for Acute Ischemic Stroke |
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| Peng Jingyu,Li Guanglai. Progress in Research on Neuroprotective Agents for Acute Ischemic Stroke[J]. Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease, 2005, 3(8): 722-724 |
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| Authors: | Peng Jingyu Li Guanglai |
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| Affiliation: | Taiyuan 030001 |
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| Abstract: | The mechanisms contributed to ischemic brain injury involve excitotoxicity, calcium overload, free radical reaction, depolarization surrounding infarct, inflammation and apoptosis. Neuroprotection is one of main therapeutic strategies for acute ischemic stroke.Neuroprotective agents that were studied by clinical trials are calcium channel antagonists, excitatory amino acid receptor antagonists, GABA receptor agonists, Antioxidants and free radical scavengers. However, so far none of the drugs have been proven conclusively to be effective for ischemic brain injury. |
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| Keywords: | acute ischemic stroke neuroprotective agents calcium channel blocker |
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