| 透皮促进剂对吡罗昔康体外渗透的影响 |
| |
| 引用本文： | 徐广庆,奚念朱.透皮促进剂对吡罗昔康体外渗透的影响[J].中国药理学报,1991,12(3):235-238. |
| |
| 作者姓名： | 徐广庆 奚念朱 |
| |
| 摘 要： |
|
| 关 键 词： | 透皮给药 吡罗昔康 渗透性 氮酮 |
Effect of enhancers on cutaneous permeation of piroxicam in vitro] |
| |
| G Q Xu,N Z Xi,G S Chen,X G Jiang,H N Xu.Effect of enhancers on cutaneous permeation of piroxicam in vitro][J].Acta Pharmacologica Sinica,1991,12(3):235-238. |
| |
| Authors: | G Q Xu N Z Xi G S Chen X G Jiang H N Xu |
| |
| Institution: | Division of Biopharmaceutics, Shanghai Medical University, China. |
| |
| Abstract: | Enhancing effects on the permeation of piroxicam (Pir) through excised hairless mouse (inbred HRS mice) skin were investigated by measuring flux. Azone 1% was found to be the most effective enhancer studied, increasing the flux about 21 times. The effect of Azone was enhanced by the presence of propylene glycol. Oleic acid, ethylacetate, and ethanol promoted the diffusion of Pir. Other enhancers, such as DMSO, PEG 400, acetone, urea and salicylic acid, showed little or no effect. Pir-beta-cyclodextrin inclusion compound increased the flux about 3 times. The results revealed that lipophilic enhancers were more effective than lipophobic ones. |
| |
| Keywords: | |
| 本文献已被 维普 等数据库收录！ |
|
