| 丹酚酸B抗前列腺肿瘤的作用 |
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| 引用本文： | 宋晓冬,杨玥,杨军厚,谭秀华,郭银汉.丹酚酸B抗前列腺肿瘤的作用[J].滨州医学院学报,2007,30(1):11-12. |
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| 作者姓名： | 宋晓冬 杨玥 杨军厚 谭秀华 郭银汉 |
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| 作者单位： | 滨州医学院生物学教研室,滨州市,256603;北京东方科技发展有限公司 |
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| 摘 要： | 目的 观察丹酚酸B抗前列腺肿瘤的作用.方法 采用光镜观察形态变化、台盼蓝计数死细胞数、MTT测定细胞活力、流式细胞仪检测细胞凋亡率评价丹酚酸B的抗肿瘤作用.结果 丹酚酸B 500 μg/ml具有抗前列腺肿瘤作用,引起肿瘤细胞凋亡.结论 经丹酚酸B作用后的BPH1-C5细胞发生凋亡,丹酚酸B具有抗肿瘤作用.
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| 关 键 词： | 丹酚酸B 前列腺肿瘤 凋亡 |
| 文章编号： | 1001-9510（2007）01-0011-02 |
| 收稿时间： | 2006-10-20 |
| 修稿时间： | 2006年10月20日 |
The effect of salvianolic acid B on a nontumorigenic human prostatic epithelial cell line |
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| SONG Xiaodong, YANG Yue ,YANG Junhou et al.The effect of salvianolic acid B on a nontumorigenic human prostatic epithelial cell line[J].Journal of Binzhou Medical College,2007,30(1):11-12. |
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| Authors: | SONG Xiaodong YANG Yue YANG Junhou |
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| Institution: | Binzhou Medical Universitg, Binzhou 256603 |
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| Abstract: | Objective To investigate the inhibiting effect of salvianolic acid B(SA-B) on a nontumorigenic human prostatic epithelial cell line.Methods By variable cellular biological techniques including light microscopy,cell counting-trypan blue staining,MTT method and flow cytometer.Results Light microscopy reveals the BPH1-C5 treated cells polymorphism.Cell counting-trypan blue staining and MTT results show the treated cells viabilities induced;Flow cytometer reveals the BPH1-C5 treated cells underwent apoptosis.Conclusion The BPH1-C5 cells treated salvianolicacid B underwent the morphological and functional alterations including apoptosis and necrosis. |
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| Keywords: | BPH1-C5 cell salvianolic acid B apoptosis |
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