| 人巨细胞病毒活动性感染与习惯性流产的关系探讨 |
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| 引用本文： | 宁琳,贾卉. 人巨细胞病毒活动性感染与习惯性流产的关系探讨[J]. 中国医药导报, 2011, 8(34): 46-47 |
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| 作者姓名： | 宁琳 贾卉 |
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| 作者单位： | 1. 陕西省妇幼保健院妇科,陕西西安,710003
2. 陕西省妇幼保健院医学实验中心,陕西西安,710003 |
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| 摘 要： | 目的：探讨人巨细胞病毒（HCMV）活动性感染与习惯性流产的关系。方法：选择2008年5月。2010年5月我院妇产科收治的反复性流产孕妇40例作为研究组，选择同期体检正常孕妇50例作为对照组，采集两组患者外周血，离心分离出有核细胞及血浆，采用实时荧光定量PCR和免疫荧光法检测HCMV-DNA和HCMVpp65抗原，分析HCMVpp65抗原阳性与流产的关系及两种检测方法的一致性。结果：研究组HCMVpp65抗原阳性率明显高于对照组，两组比较，差异有统计学意义（X2=7．69，P〈0．05）；研究组中流产次数多的孕妇，HCMVpp65抗原阳性率明显高于流产次数相对较少的孕妇，差异有统计学意义（x2=8．58，P〈0．05）。研究组中实时荧光定量PCR检测HCMV—DNA和免疫荧光法检测HCMVpp65抗原的一致性较好，达92．5％。结论：孕妇习惯性流产与其体内巨细胞病毒活动性感染有重要联系．习惯性流产孕妇HCMVpp65抗原检测与HCMV—DNA有良好的一致性，可作为习惯性流产的早期判断指标。
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| 关 键 词： | 人巨细胞病毒 活动性感染 习惯性流产 |
Relationship between HCMV active infection and habitual abortion |
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| NING Lin,JIA Hui. Relationship between HCMV active infection and habitual abortion[J]. China Medical Herald, 2011, 8(34): 46-47 |
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| Authors: | NING Lin JIA Hui |
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| Affiliation: | NING Lin1,JIA Hui2 1.Department of Gynecology,Maternal and Child Care Service Centre of Shaanxi Province,Xi'an 710003,China,2.Medical Experimental Center |
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| Abstract: | Objective:To investigate the relationship between human cytomegalovirus(HCMV) active infection and recurrent spontaneous abortion(RSA).Methods:40 cases of RSA pregnant women in our hospital from May 2008 to May 2010 were selected as study group,and 50 cases of normal pregnant women were selected as control group.Peripheral blood of two groups were collected,mononuclear cells and plasma were centrifuged,then HCMV-DNA and HCMVpp65 antigen were detected by real-time PCR and immunofluorescence.The relationship ... |
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| Keywords: | Human cytomegalovirus Active infection Habitual abortion |
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