抗环瓜氨酸肽抗体对类风湿关节炎的诊断价值

目的：探讨抗环瓜氨酸肽（cyclic citrullinated peptide，CCP）抗体在类风湿关节炎（rheumatoid arthritis，RA）患者中的水平变化及临床应用价值。方法：收集RA患者血清68例，并以68例非RA患者血清作对照。采用双抗体夹心酶联免疫吸附法测定血清抗-CCP抗体，同时检测特种蛋白类风湿因子（RF），进行统计学分析。结果：抗-CCP抗体的特异性（95．6％）明显高于RF（69．1％），RA组患者两项指标的阳性率明显高于非RA组患者（P〈0．01）。RF诊断RA的敏感性（80．9％）高于抗-CCP抗体（77．9％），但差异无统计学意义（P〉0．05）。联合检测敏感性（47．1％）较单独检测有所减低，但特异性增高明显，高达100．0％。结论：抗-CCP抗体在诊断RA中有很高的特异性，联合检测RF可以早期诊断RA，提高RA诊断率。动态监测抗-CCP抗体，RF有助于观察RA病情变化。

Study on diagnotic values of serum anti-CCP antibody for patients with rheumatoid arthritis

Objective:To investigate the changal and clinical values of serum anti-CCP antibody in patients with rheumatoid arthritis.Methods:The serum of 68 RA patients was collected and the serum of 68 non-RA patients was as control group.The serum anti-CCP antibody and RF levels of patients with rheumatoid arthritis and with other rheumaticdisea were measured and analyzed.Results:The specificity of anti-CCP was higher than that of RF(95.6% vs 69.1%).The positive rates of the index in RA group were higher than those ...