颈动脉粥样硬化、C反应蛋白与急性脑梗死的关系

目的探讨颈动脉硬化和C反应蛋白与急性脑梗死的关系。方法采用彩色多普勒超声检测86例急性脑梗死患者的颈动脉内膜,免疫比浊法测定其血清C反应蛋白水平,并与40例同期住院的非脑血管疾病患者作对照。结果脑梗死组颈动脉内膜斑块明显多于对照组(P<0.01),且以软斑和混合斑为主,而对照组以硬斑为主;脑梗死组C反应蛋白水平为9.85±2.28 mg/L,显著高于对照组的5.28±1.23 mg/L(P<0.01);软斑、混合斑、硬斑、正常颈动脉、内膜毛糙组C反应蛋白水平分别为9.80±2.43 mg/L、10.72±2.55 mg/L、7.46±2.54 mg/L、6.15±1.71 mg/L及6.38±1.96 mg/L。前两组与后三组比较均有显著性差异(P<0.01),后三组之间比较没有显著性差异。结论急性脑梗死患者颈动脉斑块明显增多,C反应蛋白水平明显升高,C反应蛋白水平可以反应颈动脉斑块的性质和稳定性。

The Clinical Study about the Relationship between Carotid Atherosclerosis,C-Reactive Protein and Acute Cerebral Infarction

Aim To investigate the relationship between carotid atherosclerosis,C-reactive protein(CRP) and acute cerebral infarction. Methods Histological changes of carotid artery were observed by color Doppler and the serum CRP were evaluated in 86 patients with acute cerebral infarction,compared with the control group which contained 40 non-cerebral infarction patients. Results Incidence of carotid artery endothelial plaque in patients with acute cerebral infarction was significantly higher than those of control group(p<0.01). In patients with acute cerebral infarction,soft plaque and mixed plaque were predominant while hard plaque were predominant in control group,there were significant difference between the two groups(p<(0.01)).Serum CRP levels in patients with cerebral infarction were obviously higher than those of control group(p<0.01).Serum CRP levels in 5 groups were respectively 9.80±2.43 mg/L,10.72±2.55 mg/L,7.46±2.54 mg/L,6.38±1.96 mg/L and 6.15±1.71 mg/L,which histological changes of carotid artery endothelial were soft plaque,mixed plaque,hard plaque,crude endothelium and normal,the levels of serum CRP in soft plaque group and mixed plaque group were higher than those of hard plaque group,crude endothelium group and nomal group(p<0.01). Conclusion Incidence of carotid artery endothelial plaque and serum CRP levels were obviously increased in patients with acute cerebral infarction.Increase of the serum CRP levels can represent the properties and stability of carotid artery plaque.