氯吡格雷联合阿司匹林肠溶片和低分子肝素钙治疗不稳定型心绞痛61例临床观察

目的观察氯吡格雷联合阿司匹林和低分子肝素钙治疗不稳定型心绞痛（UA）的临床疗效和安全性。方法122例UA患者随机分为治疗组和对照组各61例。治疗组给予氯吡格雷、阿司匹林肠溶片和低分子肝素钙治疗。对照组给予阿司匹林肠溶片和低分子肝素钙治疗，观察2组疗效和药物不良反应。结果治疗组总有效率为93．4％高于对照组的73．8％，差异有统计学意义（P〈0．05）。治疗组心绞痛发作次数、持续时间、发作间隔时间等改善情况均优于对照组，差异有统计学意义（P〈0．05），2组治疗前后凝血指标及药物不良反应情况比较，差异无统计学意义（P〉0．05）。结论氯吡格雷、阿司匹林肠溶片和低分子肝素钙联合治疗UA疗效好、且安全可靠。

Clinical observation of clopidogrel in combination with aspirin enteric-coated tablets and low molecular weight heparin treatment of unstable angina pectoris of 61 cases

Objective To observe the clinical efficacy and safety of clopidogrel in combination with aspirin and low molecular weight heparin treatment of unstable angina. Methods 122 patients with unstable angina were randomly divided into treatment group and control group of 61 cases. Treatment group was treated with clopidogrel, aspirin enteric-coated tablets and low molecular weight heparin treatment;control group was given aspirin and low molecular weight heparin treatment, observed the efficacy and adverse drug reactions of the two groups. Results The total effective rate of the treatment group was 93.4%, higher than that of 73.8% of control group （ P 〈 0.05 ） ; and the improvements of frequency of angina attacks, duration, onset interval of time were better than the control group （ P 〈 0.05 ）, the differences of coagulation indicators and adverse drug reactions,were not statistically significant （ P 〉 0.05 ）. Conclusion Aspirin enteric-coated tablets and low molecular weight heparin calcium in the treatment of unstable angina pectoris is good, safe and reliable.