左氧氟沙星与阿奇霉素联用阿莫西林克拉维酸钾治疗社区获得性肺炎对照分析

目的比较左氧氟沙星与阿奇霉素联用阿莫西林克拉维酸钾治疗社区获得性肺炎的临床疗效、安全性、成本-效果。方法将80例门诊诊治的社区获得性肺炎轻．中度患者，随机分为左氧氟沙星治疗组与阿奇霉素联用阿莫西林克拉维酸钾对照组，观察两组患者的临床疗效，不良反应、成本-效果比较。结果治疗组43例患者，痊愈35例（81．4％），显效4例（9．3％），总有效率为90．7％，不良反应率为9．3％，平均抗生素费用为52．5元；对照组37例患者，痊愈30例（81．1％），显效4例（10．8％），总有效率为91．9％，不良反应率为8．1％，平均抗生素费用为90．9元。结论左氧氟沙星与阿奇霉素联用阿莫西林克拉维酸钾门诊治疗社区获得性肺炎的临床疗效、安全性差异无统计学意义，成本-效果比较，左氧氟沙星优于阿奇霉素联用阿莫西林克拉维酸钾。

Comparison of Levofloxacin Alone and Azithromycin Combined with Amoxicillin and Clavulanate Potassium for Patients with Community-acquired Pneumonia

To evaluate the efficacy, the safety and cost-effectiveness in patients with community-ac- quired pneumonia（CAP） in comparison with therapy using levofloxacin alone and using a combination of az- ithromycin plus amoxicillin and clavulanate potassium. Methods 80 patients with light and moderate CAP were randomly divided into two groups： levofloxaein alone and azithromycin plus amoxicillin, and the efficacy, the side-effect and the cost-effectiveness were observed. Results From 43 patients in the levofloxacin group, 35 patients（81.4% ） were clinically cured and 4 patients（9. 3% ） were improved. The total effective rate was 90. 7%. And from 37 patients in the azithromycin plus amoxicillin group, 30 patients（ 81.1% ） were clinically cured and 4 patients（ 10. 8% ） were improved. The total effective rate was 91.9%. The rates of side effects were 9. 3% and 8.1% respectively. And the average cost of the treatment were 52. 5yuan and 90. 9 yuan respectively. Conclusion There are no significant differences in the efficacy and the safety between the 2 groups in treating community-acquired pneumonia. Yet the levoiloxacin is superior to azithromycin plus amoxicillin and clavulanate potassium in comparison with the cost-effectiveness.