| 肿瘤微环境对肝细胞癌血管生成的影响 |
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| 引用本文： | 覃小珊,张彩灵,黄赞松.肿瘤微环境对肝细胞癌血管生成的影响[J].世界华人消化杂志,2020,28(12):493-500. |
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| 作者姓名： | 覃小珊 张彩灵 黄赞松 |
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| 作者单位： | 右江民族医学院附属医院消化内科广西壮族自治区百色市533000;右江民族医学院研究生学院广西壮族自治区百色市533000;右江民族医学院研究生学院广西壮族自治区百色市533000;右江民族医学院附属医院消化内科广西壮族自治区百色市533000;广西肝胆疾病临床医学研究中心广西壮族自治区百色市533000 |
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| 基金项目： | 研究生教育创新项目;广西自然科学基金;广西医药卫生自筹经费计划课题;广西科技基地和人才专项广西肝胆疾病临床医学研究中心研究课题 |
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| 摘 要： | 肝癌是危害人类健康的主要恶性肿瘤之一,而肝细胞癌(hepatocellular carcinoma,HCC)是肝癌这种异质性恶性疾病中最常见的组织学分型.肿瘤微环境(tumor microenvironment,TME)是一个由肿瘤细胞及肿瘤相关基质共同构成的动态系统.HCC可以通过多种血管生成模式形成肿瘤相关血管,已有研究表明TME各组分通过多种方式介导HCC的血管生成,使其临床抗血管生成治疗面临严峻挑战.本文就HCC的血管生成模式、TME对HCC血管形成调控的研究进展予以综述,供肝癌基础与临床研究参考.
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| 关 键 词： | 肿瘤微环境 肝细胞癌 血管生成 影响因素 |
Influence of tumor microenvironment on angiogenesis in hepatocellular carcinoma |
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| Xiao-Shan Qin,Cai-Ling Zhang,Zan-Song Huang.Influence of tumor microenvironment on angiogenesis in hepatocellular carcinoma[J].World Chinese Journal of Digestology,2020,28(12):493-500. |
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| Authors: | Xiao-Shan Qin Cai-Ling Zhang Zan-Song Huang |
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| Institution: | (Department of Gastroenterology,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,Guangxi Zhuang Autonomous Region,China;Graduate School of Youjiang Medical University for Nationalities,Baise 533000,Guangxi Zhuang Autonomous Region,China;Guangxi Clinical Research Center for Hepatobiliary Diseases,Baise 533000,Guangxi Zhuang Autonomous Region,China) |
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| Abstract: | Liver cancer is one of the main malignant tumors that endanger human health,and hepatocellular carcinoma(HCC)is the most common histological type of this heterogeneous cancer.The tumor microenvironment(TME)is a dynamic system composed of tumor cells and tumor-related stroma.HCC can form tumor-related blood vessels through a variety of angiogenesis modes.Previous studies have shown that various components of TME mediate HCC angiogenesis in multiple ways,which brings big challenges to clinical anti-angiogenesis therapy.This article reviews the research progress of HCC angiogenesis model and the role of TME in the regulation of HCC angiogenesis,with an aim to provide a reference for basic and clinical research of liver cancer. |
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| Keywords: | Tumor microenvironment Hepatocellular carcinoma Angiogenesis Influencing factors |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
