内皮素-1在血管平滑肌细胞增殖作用中的研究进展

血管重构是血管壁功能和结构异常改变的过程,涉及血管内皮细胞、血管平滑肌细胞和细胞外基质的病理改变。血管平滑肌细胞增殖在血管重构中起关键性的作用。内皮素-1是一种活性多肽,参与调控血管平滑肌细胞收缩、增殖、迁移和基因表达等多项细胞功能。内皮素-1在平滑肌细胞增殖的作用机制可能是防止血管重构的关键靶点。

Endothelin-1 in Proliferation of Vascular Smooth Muscle Cells

Vascular remodeling is a process of abnormal changes in function and structure of blood vessel walls,involving the pathological changes in vascular endothelial cells,vascular smooth muscle cells and extracellular matrices.Vascular smooth muscle cell proliferation plays a key role in vascular remodeling.Endothelin-1 is an active polypeptide involved in the regulation of vascular smooth muscle cell contraction,proliferation,migration,gene expression and other cellular functions.The mechanism of action of endothelin-1 in smooth muscle cell proliferation may be a key target for preventing vascular remodeling.