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Pituitary volume in teenagers with first-presentation borderline personality disorder |
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| Authors: | Belinda Garner Andrew M Chanen Lisa Phillips Dennis Velakoulis Stephen J Wood Henry J Jackson Christos Pantelis Patrick D McGorry |
| Institution: | aORYGEN Research Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia bORYGEN Youth Health, Northwestern Mental Health, Melbourne, Australia cSchool of Behavioural Sciences, The University of Melbourne, Melbourne, Australia dMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, and Melbourne Health, Melbourne, Australia eBrain Research Institute, Austin and Repatriation Medical Centre, Melbourne, Australia |
| Abstract: | This study used magnetic resonance imaging to examine pituitary gland volume (PGV) in teenage patients with a first presentation of borderline personality disorder (BPD). No difference in PGV was observed between healthy controls (n = 20) and the total BPD cohort (n = 20). However, within the BPD cohort, those exposed to childhood trauma (n = 9) tended to have smaller pituitaries (− 18%) than those with no history of childhood trauma (n = 10). These preliminary findings suggest that exposure to childhood trauma, rather than BPD, per se, might be associated with reduced PGV, possibly reflecting hypothalamic–pituitary–adrenal axis dysfunction. |
| Keywords: | MRI HPA axis Childhood trauma |
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