Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential

Authors:	Masood?A?Shammas,Hemanta?Koley,Ramesh?B?Batchu,Robert?C?Bertheau,Alexei?Protopopov,Nikhil?C?Munshi,Raj?K?Goyal authors-affiliations__indexes u-inline-list" data-role=" AuthorsIndexes" > mailto:Raj_Goyal@hms.harvard.edu" title=" Raj_Goyal@hms.harvard.edu" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	(1) Center for Swallowing and Motility Disorders, VA Boston Healthcare System, Boston, MA 02132, USA;(2) Research and Development, VA Boston Healthcare System, Boston, MA 02132, USA;(3) Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA;(4) Medicine, Beth Israel Hospital, Boston, MA 02115, USA;(5) Medicine, Harvard Medical School, Boston, MA 02115, USA

Abstract:	Background In cancer cells, telomerase induction helps maintain telomere length and thereby bypasses senescence and provides enhanced replicative potential. Chemical inhibitors of telomerase have been shown to reactivate telomere shortening and cause replicative senescence and apoptotic cell death of tumor cells while having little or no effect on normal diploid cells.

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