Mutations in <Emphasis Type="Italic">APC</Emphasis>, <Emphasis Type="Italic">CTNNB1</Emphasis> and <Emphasis Type="Italic">K-ras</Emphasis> genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study

Authors:	Margreet?Lüchtenborg,Matty?P?Weijenberg author-information" > author-information__contact u-icon-before" > mailto:mp.weijenberg@epid.unimaas.nl" title=" mp.weijenberg@epid.unimaas.nl" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Petra?A?Wark,A?Merdan?Saritas,Guido?MJM?Roemen,Goos?NP?van Muijen,Adriaan?P?de Bru?ne,Piet?A?van den Brandt,Anton?FPM?de Goeij

Affiliation:	(1) Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Department of Epidemiology, Maastricht University, Maastricht, The Netherlands;(2) Division of Human Nutrition, Wageningen University, Wageningen, the Netherlands;(3) Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Department of Pathology, Maastricht University, Maastricht, The Netherlands;(4) Department of Pathology, University Medical Centre St. Radboud, Nijmegen, The Netherlands;(5) Research Institute Growth and Development (GROW), Department of Pathology, Maastricht University, Maastricht, The Netherlands

Abstract:	Background The early to intermediate stages of the majority of colorectal tumours are thought to be driven by aberrations in the Wnt (APC, CTNNB1) and Ras (K-ras) pathways. A smaller proportion of cancers shows mismatch repair deficiency. The aim of this study was to analyse the co-occurrence of these genetic alterations in relation to tumour and patient characteristics.

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