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| 雷公藤提取物对戊巴比妥钠处理大鼠下丘脑-垂体-肾上腺轴的影响 | |
| 引用本文： | 陈龙,茆文杰,黄光照,张益鹄,刘世新. 雷公藤提取物对戊巴比妥钠处理大鼠下丘脑-垂体-肾上腺轴的影响[J]. 中国临床药学杂志, 2010, 0(1): 14-17 |
| 作者姓名： | 陈龙 茆文杰 黄光照 张益鹄 刘世新 |
| 作者单位： | 复旦大学上海医学院法医学系;华中科技大学同济医学院法医学系; |
| 摘 要： | 目的研究雷公藤醋酸乙酯提取物（船）对戊巴比妥钠抑制大鼠下丘脑-垂体-肾上腺轴（HPAA）的刺激作用。方法给大鼠连续14d戊巴比妥钠（35mg·kg^-1，SC，bid）＋TWEE（50mg·k^-1，ig），同时设置对照组和模型组，分别从形态学（腿染色、Feulgen染色、FOS、JUN、PCNA和ACTH免疫组织化学染色，电镜观察）和功能（血清皮质酮、血浆ACrH检测）两方面观察TWEE对戊巴比妥钠抑制大鼠下丘脑-垂体-肾上腺轴的影响。结果戊巴比妥钠抑制下丘脑后，TWEE对肾上腺、垂体仍有一定程度的刺激作用，但TWEE对戊巴比妥钠阻断的下丘脑以及血浆ACTH和血清皮质酮没有影响。结论TWEE刺激HPAA可能是通过下丘脑或下丘脑以上的神经组织，然后再影响垂体和肾上腺；而其直接刺激垂体及肾上腺的作用较弱。 |
| 关 键 词： | 雷公藤醋酸乙酯提取物 戊巴比妥钠 下丘脑-垂体-肾上腺轴 |
Effect of the extract of Tripterygium wilfordii on hypothalamus-pituitary-adrenal axis in rats pre-treated by pentobarbital sodium |
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| CHEN Long,MAO Wenjie,HUANG Guangzhao,ZHANG Yihu,LIU Shixin. Effect of the extract of Tripterygium wilfordii on hypothalamus-pituitary-adrenal axis in rats pre-treated by pentobarbital sodium[J]. Chinese Journal of Clinical Pharmacy, 2010, 0(1): 14-17 | |
| Authors: | CHEN Long MAO Wenjie HUANG Guangzhao ZHANG Yihu LIU Shixin |
| Affiliation: | 1 Department of Forensic Medicine/a>;Shanghai Medical College/a>;Fudan University/a>;Shanghai 200032/a>;China/a>;2 Department of Forensic Medicine/a>;Tongji Medical College/a>;Huazhong University of Science Technology/a>;Wuhan 430030/a>;China |
| Abstract: | AIM To study the stimulatory effect of the ethylacetate extract of Tripterygium wilfordii(TWEE) on hypothalamus-pituitary-adrenal axis(HPAA) in rats pre-treated by pentobarbital sodium.METHODS A total of 18 male Wister rats were randomly divided into three groups,control group,pentobarbital sodium group and pentobarbital sodium + TWEE group(TWEE by oral route at the same time).To observe the effects of TWEE on HPAA in Wister rats pre-treated with pentobarbital sodium by both the function and morphology aspe... |
| Keywords: | ethylacetate extract of Tripterygium wilfordii pentobarbital sodium hypothalamus-pituitaryadrenal axis |
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