左旋聚乳酸可吸收骨钉两种灭菌法效果评价

目的评价左旋聚乳酸可吸收骨钉经环氧乙烷灭菌和^60Co-γ辐照灭菌的效果。方法将左旋聚乳酸可吸收骨钉放人环氧乙烷灭菌器中灭菌，灭菌后将材料置于空气中静置5d，以清除残留的环氧乙烷；另将左旋聚乳酸可吸收骨钉采用^60Co-γ辐照灭菌装置灭菌，吸收剂量15kGy。然后对2种方法灭菌的骨钉分别进行性能表征。结果与左旋聚乳酸可吸收骨钉初始弯曲强度相比，经2种方法灭菌的骨钉弯曲强度均无明显下降（P〉0．05）；与左旋聚乳酸可吸收骨钉初始分子量相比，经^60Co-γ辐照灭菌的骨钉分子量明显减小，下降约11％，表明材料发生降解；经环氧乙烷灭菌的骨钉分子量无明显变化，下降约3％，表明材料未发生明显降解。结论左旋聚乳酸可吸收骨钉以环氧乙烷灭菌为佳。

Evaluation of the sterilizing efficiency on absorbable poly-L-lactide screws with two sterilants

Objective To evaluate the sterilizing efficiency ofabscrbable poly-L-lactide (PLLA) screws sterilized with ethylene oxide and 60Co-γ radial. Methods One group of PLLA screws was sterilized in the ethylene oxide sterilization ease. In order to eliminate the rudimental ethylene oxide, the sterilized screws was put in the air for five days. The other group of PLLA screws was sterilized with 60Co-γ radial with absorbable dose of 15 kGy. Then all sterilized screws were characterized. Results Compared with the primal bend intensity of the PLLA screws, the bend intensity of sterilized screws did not descend remarkably (P＞0.05). Compared with the primal molecular weight of the PLLA screws, the molecular weight of screws with 60Co-γ radiation sterilization re-markably decreased 11%. It indicated that the material had degraded. The molecular weight of screws with ethylene oxide sterilization ordy decreased 3%. It indicated that the material didn't degrade obviously. Conclusion Ethylene oxide sterilization is a better way for sterilizing absorbable PLLA screws.