新生儿硬肿症脂质过氧化物变化的观察

为探讨脂质过氧化损伤及自由基在新生儿硬肿症发病机理中的作用，将观察对象分为疾病组和对照组，疾病组于入院时，对照组于出生后１周内取静脉血检测血浆脂质过氧化物及红细胞超氧化物歧化酶含量。

Observation on the changes of lipid peroxidation in neonates with sclerema]

Thirty-six hospitalized newborn infants with sclerema (case group), which were divided into mild group(n = 18) and severe group(n = 18), and 28 normal neonates (normal control group) were selected to measure the changes of blood lipid peroxidation (LPO) and superoxide dismutase(SOD) so as to study the role of free radicals and lipid peroxide injury the pathogenesis of the entity. The results showed that the plasma LPO contents were significantly increased and SOD were significantly decreased in the case group when compared with those in the normal group (P < 0.01). The plasma LPO was significantly higher and SOD activity was significantly lower in the severe group than those in the mild group (P < 0.01). The study indicates that the free radicals produced in sclerema neonatorum are great in amount and suggests that free radicals possibly participate in the pathogenesis of the disease.