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| 某些中药有效成分对体外非酶促糖基化的抑制作用 | |
| 引用本文： | 隋立荣,黄翠玲,李才.某些中药有效成分对体外非酶促糖基化的抑制作用[J].中国中医药信息杂志,2005,12(4):25-26. |
| 作者姓名： | 隋立荣 黄翠玲 李才 |
| 作者单位： | 1. 北京市第六医院,北京,100007 2. 北京市中西医结合医院,北京,100039 3. 白求恩医科大学,吉林,长春,130021 |
| 摘 要： | 目的探讨某些中药有效成分对非酶促糖基化(糖基化)反应的抑制作用。方法用荧光分光光度计测定某些中药成分在体外白蛋白糖基化系统的荧光值。结果阿魏酸、刺五加皂苷和大黄醇提物对糖基化有较好的抑制作用。以氨基胍作为参比,对高级糖化终末产物(AGEs)形成的相对抑制率分别为95.21%、94.75%、94.75%。结论某些中药是抑制糖尿病病人体内AGEs形成、防止并发症的候选药物。 |
| 关 键 词： | 阿魏酸 刺五加皂苷 体外 非酶促糖基化 |
| 文章编号： | 1005-5304(2005)04-0025-02 |
| 修稿时间： | 2004年5月31日 |
The Inhibitory Effects of some Chinese Herb-Components on Nonenzymatic Glycosylation in Vitro |
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| SUI Li-rong,HUANG Cui-Ling,LI Cai.The Inhibitory Effects of some Chinese Herb-Components on Nonenzymatic Glycosylation in Vitro[J].Chinese Journal of Information on Traditional Chinese Medicine,2005,12(4):25-26. | |
| Authors: | SUI Li-rong HUANG Cui-Ling LI Cai |
| Abstract: | Objective To analyze the inhibitory effects of some Chinese herb components on the nonenzymatic glycosylation (glycosylation). Methods To detect the fluorescence values of some Chinese herb components in an albumin glycosylating system in vitro with fluorescenmetry. Result Ferulic Acid, B1Eloutheroside B1 and Rheum Officinale exhibited inhibitory effects on albumin glycosylation. The relatively inhibitory rate on formation of advanced glycosylation end products (AGEs) was 95.21%, 94.75%, 94.75%, respectively, as compared with reference reagent, aminoguanidine. Conclusion Some Chinese herbs are candidate medicine that inhibite the formation of AGEs and prevent diabetic chronic complication. |
| Keywords: | Ferulic acid B1Eloutheroside B1 in vitro nonenzymatic glycosylation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |