Analysis of a cytoskeleton-associated kinase PEAK1 and E-cadherin in gastric cancer |
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| Affiliation: | 1. Department of Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China;2. Department of Oncosurgery, Anyang Tumor Hospital, Anyang, Henan Province, PR China;3. Department of Pathology, Anyang Tumor Hospital, Anyang, Henan Province, PR China;1. Department of Pathology, Samsun Training and Research Hospital, Turkey;2. Department of Pathology, 19 Mayis University, Samsun, Turkey;1. National & Regional United Engineering Laboratory of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, Third Military Medical University, Chongqing 400038, China;2. Department of Orthopedic Surgery, Affiliated Hospital of Bengbu Medical College, Bengbu 233030, Anhui Province, China;3. Department of Neurobiology, Chongqing Key Laboratory of Neurobiology, Third Military Medical University, Chongqing 400038, China;1. Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt;2. Department of Public Health, National Liver Institute, Menoufia University, Egypt;3. Faculty of Applied Medical Sciences, Taif University, Taif, Saudi Arabia;4. Department of Medical Biochemistry, Faculty of Medicine, Al-Azhar University, Egypt;5. Department of Medical Laboratory Sciences, Taif University, College of Applied Medical Sciences, Taif, Saudi Arabia;1. Department of Pathology, Erasme Hospital, Brussels, Belgium;2. Department of Pathology, Universitair Ziekenhuis, Brussels, Belgium;1. Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Brazil;2. Department of Small Animal, Universidade Federal de Santa Maria, Brazil;3. Departamento of Morphology and Histology, Universidade Federal de Santa Maria, Brazil;4. Department of Production and Control of Medicines, Faculty of Pharmacy, Universidade Federal do Rio Grande do Sul, Brazil;5. Department of Animal Science, Universidade do Estado de Santa Catarina, Chapecó, Brazil |
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| Abstract: | ![]()
The expression of pseudopodium-enriched atypical kinase 1(PEAK1) has been studied in human cancers. However, their roles in gastric cancer are still unknown. In this study, gastric cancer tissue microarrays were constructed with 159 gastric cancer tissue samples, 150 non-neoplastic gastric epithelium specimens and 152 lymph node samples. Immunohistochemical staining for PEAK1 and E-cadherin was performed. Our study found negative expression of PEAK1 in 113 of 159 (71.1%) gastric cancers, in 46 of 150 (30.7%) non-neoplastic gastric epithelium tissues and in 69 of 94 (73.4%) metastatic lymph nodes. Negative expression of PEAK1 and E-cadherin associated with tumor grading, depth of invasion, lymph node metastases, pTNM stage and macroscopic type. Patients with either positive PEAK1 or E-cadherin expression had a significantly higher survival than those with negative expression. When combined, PEAK1−/E-cadherin− had a significantly poor prognosis than the rest of the patients. The expression of PEAK1 protein was positively correlated with E-cadherin in cancer tissues. Cox regression analyses showed that PEAK1, E-cadherin and PEAK1−/E-cadherin− were independent predictors of overall survival. In conclusion, our findings suggest that loss of PEAK1 may play an important role in carcinogenesis and development of gastric cancer through activating epithelial to mesenchymal transition. |
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| Keywords: | PEAK1 E-cadherin Gastric cancer Immunohistochemistry |
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